| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Review |
| Article Title |
Multilayered control of retinal stem/progenitor cell fate in the single-cell and organoid era: Developmental blueprints and regenerative opportunities
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Qi-Qi Xie, Mei-Qi Zeng, Li-Ni Mao, Shi-Jun Han, Da Sun and Zhi-Gang Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Quzhou Municipal Science and Technology Plan Project |
ZD2022218, ZD2022231 |
|
| Corresponding Author |
Zhi-Gang Zheng, Chief, Head, MD, Professor, Department of Ophthalmology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, No. 100 Minjiang Avenue, Quzhou 324000, Zhejiang Province, China. zhengzhigang0710@wmu.edu.cn |
| Key Words |
Epigenetic competence; Human retinal organoids; Metabolic state control; Müller glia; Retinal degeneration; Retinal regeneration; Single-cell multi-omics; Spatial transcriptomics |
| Core Tip |
Retinal degeneration is a structural failure that cannot be reversed by pathway modulation alone. Leveraging single-cell and spatial multi-omics from human retina and organoids, this review defines a multilayer fate-control paradigm - transcriptional instruction, epigenetic permission, and metabolic/inflammatory execution - that governs competence windows and photoreceptor vs inner-retinal outcomes. We compare major regenerative cell sources (retinal progenitors, Müller glia, ciliary marginal zone-like candidates, and human pluripotent stem cell-derived retinal pigment epithelium/photoreceptors) and translate atlas insights into actionable engineering strategies, including organoid benchmarking, staged reprogramming, and rational gene + cell combinations to enhance maturation and circuit integration. |
| Publish Date |
2026-04-20 08:05 |
| Citation |
Xie QQ, Zeng MQ, Mao LN, Han SJ, Sun D, Zheng ZG. Multilayered control of retinal stem/progenitor cell fate in the single-cell and organoid era: Developmental blueprints and regenerative opportunities. World J Stem Cells 2026; 18(4): 118621 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i4/118621.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i4.118621 |
