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Articles Published Processes
5/26/2026 3:52:08 AM | Browse: 0 | Download: 0
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Received |
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2026-01-07 06:34 |
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Peer-Review Started |
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2026-01-07 06:34 |
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First Decision by Editorial Office Director |
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2026-01-27 09:39 |
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Return for Revision |
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2026-01-27 10:24 |
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Revised |
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2026-02-02 12:31 |
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Publication Fee Transferred |
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2026-02-04 13:09 |
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Second Decision by Editor |
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2026-02-27 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-27 09:57 |
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Articles in Press |
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2026-02-27 09:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-14 05:05 |
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Publish the Manuscript Online |
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2026-05-26 03:52 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Early-onset hepatic fibrosis linking to a novel PYROXD2 mutation: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Yao Jiang, Rong-Qiang Liu, Meng-Juan Tang, Han-Dong Fan, Wen-Jun Yang, Ling Gong, Xiao-Xiao Mi and Jun-Ping Shi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82470599 |
| Zhejiang Provincial Natural Science Foundation of China |
LHDMZ24H030001 |
| Hangzhou Municipal Key Scientific Research Plan Project |
2025SZD1B09 |
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| Corresponding Author |
Jun-Ping Shi, MD, Department of Infectious Diseases and Hepatology, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Hangzhou 310015, Zhejiang Province, China. 20131004@hznu.edu.cn |
| Key Words |
Early-onset liver fibrosis; PYROXD2; Obesity; Hyperuricemia; Frameshift mutation; Mitochondrial dysfunction; Metabolic disorder; Case report |
| Core Tip |
For the first time, our study reports that a heterozygous frameshift mutation in the PYROXD2 gene may underlie early-onset liver fibrosis. This variant impairs the function of mitochondrial oxidoreductases, ultimately triggering metabolic disturbances and the development of early liver fibrosis. Our findings uncover a novel pathogenic variation of PYROXD2 linking to early-onset liver fibrosis, thereby providing a new rationale for the genetic diagnosis of related disorders. |
| Publish Date |
2026-05-26 03:52 |
| Citation |
Jiang ZY, Liu RQ, Tang MJ, Fan HD, Yang WJ, Gong L, Mi XX, Shi JP. Early-onset hepatic fibrosis linking to a novel PYROXD2 mutation: A case report. World J Hepatol 2026; 18(5): 118622 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i5/118622.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i5.118622 |
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