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Articles Published Processes
8/5/2026 5:45:45 AM | Browse: 1 | Download: 0
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Received |
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2026-01-07 03:46 |
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Peer-Review Started |
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2026-01-07 03:48 |
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First Decision by Editorial Office Director |
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2026-02-06 10:43 |
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Return for Revision |
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2026-02-06 10:43 |
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Revised |
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2026-02-14 08:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-28 02:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-28 05:40 |
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Articles in Press |
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2026-02-28 05:40 |
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Edit the Manuscript by Language Editor |
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2026-03-04 10:34 |
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Typeset the Manuscript |
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2026-07-29 08:29 |
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Publish the Manuscript Online |
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2026-08-05 05:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Correspondence |
| Article Title |
Lianhe Xiaozhi ointment for metabolic dysfunction-associated steatotic liver disease: A gut-liver-brain axis perspective
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tian-Ci Tang, Rui-Xi Ming, Yu-Meng Liu and Bin Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82504755 |
| Natural Science Foundation of Jiangsu Province |
BK20240907 |
| the “Lv Yang Jin Feng” Outstanding Doctor of Yangzhou |
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| the Top-level Talents Support Program of Yangzhou University |
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| Corresponding Author |
Bin Li, Assistant Professor, PhD, Institute of comparative medicine, Yangzhou University, No. 88 Daxue South Road, Yangzhou 225009, Jiangsu, China. 008480@yzu.edu.cn |
| Key Words |
Lianhe Xiaozhi ointment; Traditional Chinese medicine; Metabolic dysfunction-associated steatotic liver disease; Gut-liver-brain axis; Peroxisome proliferator-activated receptor alpha; Gut microbiota |
| Core Tip |
Lianhe Xiaozhi ointment (LXO), a multi-herb formulation, profoundly improved experimental metabolic dysfunction-associated steatotic liver disease (MASLD) through a unique mechanism linking gut microbiota modulation to peroxisome proliferator-activated receptor alpha (PPARα) activation in the liver. This letter commends the study’s comprehensive strategy (network pharmacology, omics, in vivo or in vitro validation) and situates the findings in context of emerging MASLD therapies. By comparing LXO’s outcomes to prior interventions and proposing next-step studies (e.g., Ppara knockout validation, metabolite profiling, brain inflammation assays), we underscore LXO as a concept-proof therapy that opens new avenues via the gut-PPARα-liver axis for metabolic liver disease. |
| Publish Date |
2026-08-05 05:45 |
| Citation |
Tang TC, Ming RX, Liu YM, Li B. Lianhe Xiaozhi ointment for metabolic dysfunction-associated steatotic liver disease: A gut-liver-brain axis perspective. World J Gastroenterol 2026; 32(32): 118636
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i32/118636.htm |
| DOI |
https://doi.org/10.3748/wjg.118636 |
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