BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/11/2026 6:12:02 AM | Browse: 3 | Download: 0
 |
Received |
|
2026-01-07 06:12 |
|
Peer-Review Started |
|
2026-01-07 06:12 |
|
First Decision by Editorial Office Director |
|
2026-02-27 09:03 |
|
Return for Revision |
|
2026-02-27 09:03 |
|
Revised |
|
2026-03-28 21:36 |
|
Publication Fee Transferred |
|
2026-05-13 06:59 |
|
Second Decision by Editor |
|
2026-05-09 02:37 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-05-09 11:45 |
|
Articles in Press |
|
2026-05-09 11:45 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-03 07:57 |
|
Publish the Manuscript Online |
|
2026-08-11 06:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Opinion Review |
| Article Title |
Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Irene Maier |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Irene Maier, PhD, Researcher, Department of Internal Medicine I, Medical University of Vienna, Währinger Gürtel 18-20, Vienna A-1090, Austria. irene.maier@meduniwien.ac.at |
| Key Words |
Phytochemical; Polyphenol; Liver; Proliferation; Carcinoma |
| Core Tip |
The combination of quercetin and triptolide demonstrates enhanced antitumor effects by reducing tumor growth and oxidative stress while modulating the protein kinase B/mammalian target of rapamycin signaling pathway. Plant-derived bioactive compounds and herbal formulations have shown promise in hepatocellular carcinoma therapy, particularly in combination regimens that exert anticancer and anti-inflammatory effects through modulation of the tumor microenvironment. Quercetin may also inhibit triptolide-induced liver injury and carcinogenesis by regulating the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, which is associated with cell proliferation. |
| Publish Date |
2026-08-11 06:12 |
| Citation |
Maier I. Synergistic antitumor effects of quercetin and triptolide in hepatocellular carcinoma via modulation of PI3K/AKT/mTOR and Nrf2 signaling pathways. World J Gastroenterol 2026; 32(33): 118638
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i33/118638.htm |
| DOI |
https://doi.org/10.3748/wjg.118638 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
