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Articles Published Processes
6/25/2026 8:21:21 AM | Browse: 0 | Download: 0
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Received |
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2026-01-08 06:45 |
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Peer-Review Started |
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2026-01-08 06:46 |
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First Decision by Editorial Office Director |
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2026-01-23 07:59 |
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Return for Revision |
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2026-01-23 07:59 |
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Revised |
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2026-01-30 13:53 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-16 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-23 04:08 |
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Articles in Press |
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2026-03-23 04:08 |
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Edit the Manuscript by Language Editor |
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2026-03-28 21:47 |
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Typeset the Manuscript |
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2026-05-26 09:32 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Review |
| Article Title |
Stem cell-derived immune cells in pediatric cancer therapy: From bench to bedside
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dina A Tolan, Noura A A Ebrahim, Naif S AlAli, Hoda A Ahmed, Gharam A Alharshan and Aya Mohamed Adel Arafat |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, Assistant Professor, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Stem cell-derived immunotherapy; Pediatric oncology; Induced pluripotent stem cells; Chimeric antigen receptor-based cell therapy; Natural killer cells; Allogeneic immune effectors |
| Core Tip |
Immune cells generated from pluripotent or hematopoietic stem cell sources -particularly natural killer cells, T lymphocytes, and dendritic cells - represent a promising next-generation platform for pediatric cancer immunotherapy. These systems enable standardized, renewable production and genetic optimization, offering an allogeneic alternative to patient-specific cellular products with lower graft-vs-host disease risk. Advances in cytokine modulation and genome editing technologies, including CRISPR/Cas9, have further strengthened antitumor efficacy. This review critically consolidates current preclinical and early-phase clinical findings; addresses manufacturing, safety, and pediatric ethical considerations; and defines strategic directions for clinical translation. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Tolan DA, Ebrahim NAA, AlAli NS, Ahmed HA, Alharshan GA, Arafat AMA. Stem cell-derived immune cells in pediatric cancer therapy: From bench to bedside. World J Stem Cells 2026; 18(6): 118674
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/118674.htm |
| DOI |
https://doi.org/10.4252/wjsc.118674 |
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