BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/25/2026 6:38:36 AM | Browse: 4 | Download: 0
 |
Received |
|
2026-01-19 07:26 |
|
Peer-Review Started |
|
2026-01-19 07:27 |
|
First Decision by Editorial Office Director |
|
2026-02-26 07:46 |
|
Return for Revision |
|
2026-02-26 07:46 |
|
Revised |
|
2026-03-10 19:05 |
|
Publication Fee Transferred |
|
2026-03-11 10:06 |
|
Second Decision by Editor |
|
2026-04-15 02:39 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-04-15 04:06 |
|
Articles in Press |
|
2026-04-15 04:06 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-20 06:52 |
|
Publish the Manuscript Online |
|
2026-08-25 06:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Serum anti-enteric neuronal antibodies in patients with achalasia and their association with clinical profiles
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yao-Wen Hu, Pan Tang, Tao Guo, Zhi-Feng Wang, Xiu-Cai Fang, Li-Ming Zhu, Gui-Jun Fei, Yang Chen and Xiao-Qing Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81970476 |
|
| Corresponding Author |
Xiao-Qing Li, MD, Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. lixiaoqing20060417@126.com |
| Key Words |
Achalasia; Anti-enteric neuronal antibody; Enteric nervous system; Disease severity; Treatment outcome |
| Core Tip |
Serum anti-enteric neuronal antibodies (AENA) are significantly more prevalent in patients with achalasia than in healthy subjects. This study identifies a novel dose-dependent association between AENA intensity and endoscopic disease severity, as assessed by the CARS (contents, anatomy, resistance, and stasis) score. Strong AENA positivity correlates with greater esophageal dilation and higher integrated relaxation pressure. Furthermore, AENA positivity is associated with less favorable symptomatic improvement after peroral endoscopic myotomy. These findings suggest that AENA status may serve as a valuable biomarker for identifying a more severe disease phenotype with poorer early treatment outcomes. |
| Publish Date |
2026-08-25 06:38 |
| Citation |
Hu YW, Tang P, Guo T, Wang ZF, Fang XC, Zhu LM, Fei GJ, Chen Y, Li XQ. Serum anti-enteric neuronal antibodies in patients with achalasia and their association with clinical profiles. World J Gastroenterol 2026; 32(36): 118689
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i36/118689.htm |
| DOI |
https://doi.org/10.3748/wjg.118689 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
