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Publication Name World Journal of Gastroenterology
Manuscript ID 118690
Country China
Received
2026-01-12 03:37
Peer-Review Started
2026-01-12 03:38
First Decision by Editorial Office Director
2026-02-04 10:02
Return for Revision
2026-02-04 10:02
Revised
2026-02-17 17:50
Publication Fee Transferred
Second Decision by Editor
2026-02-28 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-28 03:25
Articles in Press
2026-02-28 03:25
Edit the Manuscript by Language Editor
2026-03-04 00:46
Typeset the Manuscript
2026-05-30 17:09
Publish the Manuscript Online
2026-06-12 10:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Comparative evaluation of multimodal large language models for Mayo Endoscopic Subscore grading in ulcerative colitis
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Yi Zhao, Yue Shen, Jun-Jie He, Qun-Yan Zhou, Li-Sha Jiang, Zi-Ru Zhou, Fang-Mei An, Qiang Zhan, Jing Sun and Wei Feng
ORCID
Author(s) ORCID Number
Fang-Mei An http://orcid.org/0000-0002-6116-1989
Qiang Zhan http://orcid.org/0000-0001-5054-3028
Jing Sun http://orcid.org/0009-0005-0302-693X
Wei Feng http://orcid.org/0000-0002-6843-2067
Funding Agency and Grant Number
Funding Agency Grant Number
the Program of Jiangsu Branch of the National Clinical Research Center for Digestive Diseases JSZX202301
Basic Research Program of Jiangsu BK20231146
Key Program of Wuxi Medical Center, Nanjing Medical University WMCM202305
Doctoral Talent Fund of Wuxi People’s Hospital BSRC202408
Scientific Research Project of Wuxi Municipal Health Commission M202503
Corresponding Author Wei Feng, PhD, Department of Information, The Affiliated Wuxi People's Hospital of Nanjing Medical University, #299,Qingyang Road,Wuxi, Jiangsu, China, Wuxi 214023, Jiangsu Province, China. fengwei@njmu.edu.cn
Key Words Ulcerative colitis; Mayo Endoscopic Subscore; Endoscopic assessment; Artificial intelligence; Multimodal large language models; Diagnostic accuracy
Core Tip This single-center proof-of-concept study is the first to systematically compare five multimodal large language models for static-image-based Mayo Endoscopic Subscore grading in ulcerative colitis. The key innovation is the direct benchmarking against experienced inflammatory bowel disease physicians and the incorporation of segment-specific analyses that uncover anatomical heterogeneity in model performance. Notably, GPT-5 achieved near-expert-level accuracy without specialized tuning, highlighting its potential role in standardized endoscopic assessment.
Publish Date 2026-06-12 10:39
Citation

Zhao XY, Shen Y, He JJ, Zhou QY, Jiang LS, Zhou ZR, An FM, Zhan Q, Sun J, Feng W. Comparative evaluation of multimodal large language models for Mayo Endoscopic Subscore grading in ulcerative colitis. World J Gastroenterol 2026; 32(24): 118690

URL https://www.wjgnet.com/1007-9327/full/v32/i24/118690.htm
DOI https://doi.org/10.3748/wjg.118690
Full Article (PDF) WJG-32-118690-with-cover.pdf
Manuscript File 118690_Auto_Edited_110531-YJP.docx
Answering Reviewers 118690-answering-reviewers.pdf
Audio Core Tip 118690-audio.m4a
Biostatistics Review Certificate 118690-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 118690-conflict-of-interest-statement.pdf
Copyright License Agreement 118690-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 118690-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 118690-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 118690-non-native-speakers.pdf
Supplementary Material 118690-supplementary-material.pdf
Peer-review Report 118690-peer-reviews.pdf
Scientific Misconduct Check 118690-scientific-misconduct-check.png
Scientific Editor Work List 118690-scientific-editor-work-list.pdf
CrossCheck Report 118690-crosscheck-report.pdf