| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ao-Yun Zhang, Cong-Yi Xie, Xiao Song, Zi-Han Guo, Yu-Rou Shi, Shuai-Yan Wang, Guan-Hu Yang, Yun Liu and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation |
No. 82305376 |
| The Youth Talent Support Project of the China Acupuncture and Moxibustion Association |
No. 2024-2026ZGZJXH-QNRC005 |
| The 2024 Jiangsu Province Youth Science and Technology Talent Support Project |
No. JSTJ-2024-380 |
| Jiangsu Science and Technology Think Tank Program Project |
No. 2025-20-35 |
|
| Corresponding Author |
Tian-Cheng Xu, Academic Fellow, CEO, Chairman, Consultant, Full Professor, Head, MD, PhD, President, Professor, Visiting Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Triggering receptor expressed on myeloid cells 2; Obesity; Pancreatic macrophages; Pancreatic inflammation; Immunometabolism |
| Core Tip |
Triggering receptor expressed on myeloid cells pancreatic macrophages represent a promising therapeutic target bridging obesity, islet inflammation, and metabolic disorders. The central theme of this review focuses on the phenotypic remodeling characteristics of macrophages in obesity, the regulatory mechanisms of triggering receptor expressed on myeloid cells 2, and its impacts on macrophage-β cell crosstalk, followed by a discussion on translational prospects and challenges. |
| Publish Date |
2026-06-04 07:37 |
| Citation |
Zhang AY, Xie CY, Song X, Guo ZH, Shi YR, Wang SY, Yang GH, Liu Y, Xu TC. Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation. World J Biol Chem 2026; 17(2): 118705
|
| URL |
https://www.wjgnet.com/1949-8454/full/v17/i2/118705.htm |
| DOI |
https://doi.org/10.4331/wjbc.v17.i2.118705 |
