| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Pancreatic-liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hao-Yao Pan, Wei-Wei Chen, Jia-Xin Liang, Yi-Yang Sheng, Wen-Jing Zhang, Xue-Wen Zhu, Shuai-Yan Wang, Guan-Hu Yang, Yun Liu and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China Youth Science Fund Project |
No. 82305376 |
| Young Talent Support Program of the China Association for Acupuncture-Moxibustion |
2024-2026ZGZJXH-QNRC005 |
| 2024 Jiangsu Provincial Young Scientific and Technological Talent Support Program |
JSTJ-2024-380 |
| Talent Cultivation Program for Young Researchers (Category A), Key Laboratory of the Ministry of Education Project |
Zyqt202501 and Zyqt202503 |
|
| Corresponding Author |
Tian-Cheng Xu, Academic Fellow, CEO, Chairman, Consultant, Full Professor, Head, MD, PhD, President, Professor, Visiting Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Obesity; Pancreatic-liver axis; MiR-138-5p; ALKBH5; GLP-1/GIP dual agonists |
| Core Tip |
This minireview synthesizes the key role of the pancreas-liver axis in the pathogenesis of obesity, highlighting novel molecular mediators (e.g. adipocyte-derived exosomal miR-138-5p and hepatic ALKBH5) and neuroimmune pathways that drive pancreatic-liver crosstalk. It further discusses emerging therapeutic breakthroughs, including GLP-1/GIP dual agonists and intermittent fasting, which aim to improve metabolic outcomes and provide comprehensive strategies for obesity management and prevention of related metabolic diseases. |
| Publish Date |
2026-07-10 10:11 |
| Citation |
Pan HY, Chen WW, Liang JX, Sheng YY, Zhang WJ, Zhu XW, Wang SY, Yang GH, Liu Y, Xu TC. Pancreatic-liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs. World J Methodol 2026; 16(3): 118728
|
| URL |
https://www.wjgnet.com/2222-0682/full/v16/i3/118728.htm |
| DOI |
https://doi.org/10.5662/wjm.v16.i3.118728 |
