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8/3/2026 1:23:55 AM | Browse: 2 | Download: 1
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 118730
Country Peru
Received
2026-01-12 01:36
Peer-Review Started
2026-01-12 01:36
First Decision by Editorial Office Director
2026-01-30 09:02
Return for Revision
2026-01-30 09:02
Revised
2026-02-02 18:56
Publication Fee Transferred
Second Decision by Editor
2026-03-12 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-12 08:00
Articles in Press
2026-03-12 08:00
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-14 07:04
Publish the Manuscript Online
2026-08-03 01:23
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Minireviews
Article Title Current and forthcoming pharmacotherapies for adolescent obesity: Evidence-based review
Manuscript Source Invited Manuscript
All Author List Jenyfer M Fuentes-Mendoza, Marcio J Concepción-Zavaleta, Luisa Graciela Dongo-Dueñas, Jose Mariano J Jara-Pianto, Jhosmar Angel Sierra-Martel, Claudio Aldahir Medina-Angulo, Horus Michael Virú-Flores, Jeny J Mendoza-Godoy, Francisca E Zavaleta-Gutiérrez and José Paz-Ibarra
ORCID
Author(s) ORCID Number
Jenyfer M Fuentes-Mendoza http://orcid.org/0000-0002-4682-3999
Marcio J Concepción-Zavaleta http://orcid.org/0000-0001-9719-1875
Luisa Graciela Dongo-Dueñas http://orcid.org/0009-0004-0997-5792
Jose Mariano J Jara-Pianto http://orcid.org/0009-0001-6446-6382
Jhosmar Angel Sierra-Martel http://orcid.org/0009-0004-0536-7554
Claudio Aldahir Medina-Angulo http://orcid.org/0009-0007-4939-9883
Horus Michael Virú-Flores http://orcid.org/0000-0002-6685-9497
Jeny J Mendoza-Godoy http://orcid.org/0009-0008-2728-9859
Francisca E Zavaleta-Gutiérrez http://orcid.org/0000-0002-5497-3735
José Paz-Ibarra http://orcid.org/0000-0002-2851-3727
Funding Agency and Grant Number
Corresponding Author Marcio J Concepción-Zavaleta, Grupo de Investigación en Neurociencias, Metabolismo, Efectividad Clínica y Sanitaria, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe
Key Words Adolescent obesity; Pediatric obesity; Anti-obesity medications; Weight reduction; Adherence; Quality of life
Core Tip This minireview demonstrates that current evidence confirms that lifestyle interventions are insufficient for severe cases, proposing pharmacotherapy as a clinical necessity, where glucagon-like peptide 1 receptor agonists, especially semaglutide, are positioned as the current standard of care; while critically evaluating the horizon of dual agonists and other combinations. The article identifies new structural barriers such as high costs, global shortages, and strict insurance requirements. It highlights the urgency of conducting new direct comparisons emphasizing the need to integrate data from ongoing Food and Drug Administration-mandated post-marketing surveillance and prospective registries to monitor outcomes in pubertal maturation, bone health, and neurobiological impact.
Publish Date 2026-08-03 01:23
Citation

Fuentes-Mendoza JM, Concepción-Zavaleta MJ, Dongo-Dueñas LG, Jara-Pianto JMJ, Sierra-Martel JA, Medina-Angulo CA, Virú-Flores HM, Mendoza-Godoy JJ, Zavaleta-Gutiérrez FE, Paz-Ibarra J. Current and forthcoming pharmacotherapies for adolescent obesity: Evidence-based review. World J Clin Pediatr 2026; 15(3): 118730

URL https://www.wjgnet.com/2219-2808/full/v15/i3/118730.htm
DOI https://doi.org/10.5409/wjcp.118730
Full Article (PDF) WJCP-15-118730-with-cover.pdf
Manuscript File 118730_Auto_Edited_005634.docx
Answering Reviewers 118730-answering-reviewers.pdf
Audio Core Tip 118730-audio.mp3
Conflict-of-Interest Disclosure Form 118730-conflict-of-interest-statement.pdf
Copyright License Agreement 118730-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118730-non-native-speakers.pdf
Peer-review Report 118730-peer-reviews.pdf
Scientific Misconduct Check 118730-scientific-misconduct-check.png
Scientific Editor Work List 118730-scientific-editor-work-list.pdf
CrossCheck Report 118730-crosscheck-report.pdf