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Articles Published Processes
6/22/2026 8:40:58 AM | Browse: 0 | Download: 0
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Received |
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2026-01-12 03:26 |
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Peer-Review Started |
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2026-01-12 03:35 |
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First Decision by Editorial Office Director |
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2026-02-12 08:19 |
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Return for Revision |
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2026-02-12 08:19 |
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Revised |
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2026-02-21 05:07 |
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Publication Fee Transferred |
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2026-03-31 06:03 |
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Second Decision by Editor |
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2026-05-08 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-08 08:49 |
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Articles in Press |
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2026-05-08 08:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-09 14:37 |
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Publish the Manuscript Online |
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2026-06-22 08:40 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Spatially fractionated radiotherapy: Integrated dose heterogeneity and radiobiology for bulky tumor
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling-Ling Meng, Lin Ma, Bao-Lin Qu and Yu-Peng Di |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yu-Peng Di, Department of Radiotherapy, Air Force Medical Center, Air Force Medical University, Beijing 100142, PR China, Fucheng Road28, Beijing 100142, China. diyupeng0723@126.com |
| Key Words |
Spatially fractionated radiotherapy; Dose heterogeneity; Normal tissue sparing; Bystander-abscopal effects; Bulky radioresistant tumors |
| Core Tip |
Spatially fractionated radiotherapy (SFRT) offers a novel solution to the clinical challenge of treating bulky tumors. By creating controlled dose heterogeneity (“peaks” and “valleys”), SFRT leverages the regenerative capacity of normal tissues to maximize sparing while potentially triggering systemic antitumor immunity via bystander and abscopal effects. This article critically examines the dual mechanistic pathways of SFRT-integrating physical dose modulation with biological signaling-and reviews emerging clinical evidence suggesting its potential to safely expand the therapeutic index for difficult-to-treat malignancies. |
| Publish Date |
2026-06-22 08:40 |
| Citation |
Meng LL, Ma L, Qu BL, Di YP. Spatially fractionated radiotherapy: Integrated dose heterogeneity and radiobiology for bulky tumor. World J Clin Oncol 2026; 17(6): 118731
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i6/118731.htm |
| DOI |
https://doi.org/10.5306/wjco.118731 |
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