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Articles Published Processes
6/9/2026 9:23:55 AM | Browse: 1 | Download: 0
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Received |
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2026-01-12 03:05 |
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Peer-Review Started |
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2026-01-12 03:06 |
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First Decision by Editorial Office Director |
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2026-01-23 07:57 |
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Return for Revision |
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2026-01-23 07:57 |
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Revised |
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2026-01-25 14:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-25 09:17 |
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Articles in Press |
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2026-02-25 09:17 |
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Edit the Manuscript by Language Editor |
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2026-03-02 03:24 |
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Typeset the Manuscript |
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2026-04-24 05:33 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Observational Study |
| Article Title |
Stage-dependent and heterogeneous tumor association of Fusobacterium nucleatum in Romanian patients with colon adenocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Simona Turcu, Konstantina-Lida Prasoula, Evangelia Legaki, Florin Andrei Grama, Draga-Maria Mandi, Adrian Bordea, Catalin Andrei Dutei and Maria Gazouli |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the University of Medicine and Pharmacy ‘Carol Davila’ |
10S10/08.05.2025 |
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| Corresponding Author |
Maria Gazouli, PhD, Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, No. 176 Michalakopoulou, Athens 11527, Attikí, Greece. mgazouli@med.uoa.gr |
| Key Words |
Colorectal cancer; Fusobacterium nucleatum; Gut microbiome; Tumor heterogeneity; microRNA-21; Romanian population |
| Core Tip |
This pilot study presents the first paired tumor-adjacent tissue analysis of Fusobacterium nucleatum in Romanian patients with colon adenocarcinoma. Using quantitative real-time polymerase chain reaction, we show that tumor-associated Fusobacterium nucleatum signals are heterogeneous and stage-dependent rather than uniformly enriched. Higher bacterial signal was observed in earlier T-stage tumors, while no consistent associations were identified with demographic, surgical, or microRNA-21 expression profiles. These findings provide initial population-specific insight into tumor-microbe interactions and establish a foundation for larger, longitudinal studies evaluating the clinical relevance of colorectal cancer-associated microbiota. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Turcu S, Prasoula KL, Legaki E, Grama FA, Mandi DM, Bordea A, Dutei CA, Gazouli M. Stage-dependent and heterogeneous tumor association of Fusobacterium nucleatum in Romanian patients with colon adenocarcinoma. World J Gastrointest Oncol 2026; 18(6): 118753
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/118753.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.118753 |
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