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Articles Published Processes
8/19/2026 1:55:07 AM | Browse: 0 | Download: 0
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Received |
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2026-01-12 03:01 |
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Peer-Review Started |
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2026-01-12 03:02 |
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First Decision by Editorial Office Director |
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2026-01-23 10:05 |
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Return for Revision |
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2026-01-23 10:05 |
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Revised |
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2026-01-31 02:01 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-10 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-10 07:17 |
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Articles in Press |
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2026-03-10 07:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-10 00:20 |
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Publish the Manuscript Online |
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2026-08-19 01:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Stage-dependent prognostic value of programmed death ligand-1 expression in gastric cancer: Implications for personalized immunotherapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Koji Takahashi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Koji Takahashi, MD, Department of Gastroenterology, Eastern Chiba Medical Center, 3-6-2, Okayamadai, Togane 283-8686, Chiba, Japan. koji517@gmail.com |
| Key Words |
Gastric cancer; Programmed death ligand-1; Immune checkpoint inhibitors; Tumor microenvironment; Biomarkers; Individualized medicine |
| Core Tip |
This review reappraises programmed death ligand-1 (PD-L1) expression in gastric cancer (GC) and gastroesophageal junction cancer as a dynamic reflection of the tumor microenvironment. We examine the stage-dependent prognostic shift of PD-L1 and immune phenotypes (inflamed, excluded, and desert). By integrating phase III trial data with molecular subtypes like Epstein-Barr virus and microsatellite instability, we highlight limitations of simplified scoring. We propose personalized immunotherapy, driven by spatial analysis and dynamic monitoring, to optimize outcomes across the complex biological landscape of GC. |
| Publish Date |
2026-08-19 01:55 |
| Citation |
Takahashi K. Stage-dependent prognostic value of programmed death ligand-1 expression in gastric cancer: Implications for personalized immunotherapy. World J Gastroenterol 2026; 32(34): 118762
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i34/118762.htm |
| DOI |
https://doi.org/10.3748/wjg.118762 |
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