Publication Name	World Journal of Hepatology
Manuscript ID	11877
Country	Italy

Received	2014-06-10 08:45
Peer-Review Started	2014-06-10 10:28
To Make the First Decision	2014-07-29 11:53
Return for Revision	2014-08-07 08:25
Revised	2014-08-08 03:06
Second Decision	2014-10-10 18:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-10 18:20
Articles in Press	2014-10-10 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 09:15
Publish the Manuscript Online	2014-11-20 19:46

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of vaptans in the management of hydroelectrolytic imbalance in liver cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Antonio Facciorusso, Annabianca Amoruso, Viviana Neve, Matteo Antonino, Valentina Del Prete and Michele Barone
Funding Agency and Grant Number
Corresponding Author	Michele Barone, Professor, Gastroenterology Section, Department of Medical Sciences, University of Foggia, AOU Ospedali Riuniti, Viale Pinto, 1, 71100 Foggia, Italy. michele.barone@unifg.it
Key Words	Cirrhosis; Vaptans; Portal hypertension; Arginin vasopressin; Liver
Core Tip	Increasing evidences support the central role of renal function alterations in the pathogenesis of hydroelectrolytic imbalances in cirrhotic patients. Since Arginin Vasopressin (AVP) plays an important role in the development of refractory ascites, dilutional hyponatremia and hepato-renal syndrome, selective antagonists of AVP receptors V2 (vaptans) have been recently introduced in the therapeutic algorithm of advanced cirrhotic patients. Despite the promising results of earlier phase-two studies, randomized controlled trials failed to find significant results in terms of efficacy. Moreover, concerns on their safety profile arise. More robust data from randomized controlled trials are needed.
Publish Date	2014-11-20 19:46
Citation	Facciorusso A, Amoruso A, Neve V, Antonino M, Del Prete V, Barone M. Role of vaptans in the management of hydroelectrolytic imbalance in liver cirrhosis. World J Hepatol 2014; 6(11): 793-799
URL	http://www.wjgnet.com/1948-5182/full/v6/i11/793.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i11.793

Full Article (PDF)	WJH-6-793.pdf
Full Article (Word)	WJH-6-793.doc
Manuscript File	11877-Review.doc
Answering Reviewers	11877-Answering reviewers.pdf
Copyright License Agreement	11877-Copyright assignment.pdf
Peer-review Report	11877-Peer review(s).pdf
Scientific Misconduct Check	11877-CrossCheck.jpg
Scientific Editor Work List	11877-Scientific editor work list.pdf