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Articles Published Processes
7/13/2026 9:40:24 AM | Browse: 2 | Download: 0
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Received |
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2026-01-12 06:57 |
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Peer-Review Started |
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2026-01-12 06:59 |
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First Decision by Editorial Office Director |
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2026-02-03 08:20 |
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Return for Revision |
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2026-02-03 08:20 |
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Revised |
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2026-02-11 07:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-27 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-27 08:02 |
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Articles in Press |
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2026-03-27 08:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-26 05:18 |
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Publish the Manuscript Online |
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2026-07-13 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia -associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Qun Chen, Ying-Yue Xu, He-Lin Pan, Min Duan, Hang Ma, Yan-Ping Li and Jin-Wei Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81904175 |
| Chongqing Technological Innovation and Applied Development Special Project |
No. CSTB2022TIAD-KPX0187 |
| Young Scholars Cultivation Program of the Spleen and Stomach Diseases Branch, China Association of Chinese Medicine |
202557-001 |
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| Corresponding Author |
Jin-Wei Zhang, PhD, Chongqing General Hospital, Chongqing University, Chongqing 400000, China. jinwei.zhang@cqu.edu.cn |
| Key Words |
Spasmolytic polypeptide-expressing metaplasia; Spleen-stomach deficiency syndrome; Yiwei Xiaoyu granules; miR-7a-5p/Cdr1as; WFDC2 |
| Core Tip |
Spasmolytic polypeptide-expressing metaplasia (SPEM) represents a key precancerous stage of gastric carcinogenesis and frequently coexists with spleen-stomach deficiency syndrome (SSDS) in clinical practice. Using a combined tamoxifen-induced SPEM and SSDS mouse model, we demonstrate that Yiwei Xiaoyu granules exert sustained protective effects on gastric mucosa. Yiwei Xiaoyu granules bidirectionally regulates inflammatory cytokines, restores the miR-7a-5p/Cdr1as axis, and suppresses WFDC2 induction, thereby linking syndrome-based intervention with molecular mechanisms of gastric precancerous lesions. |
| Publish Date |
2026-07-13 09:40 |
| Citation |
Chen WQ, Xu YY, Pan HL, Duan M, Ma H, Li YP, Zhang JW. Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia -associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network. World J Gastrointest Oncol 2026; 18(7): 118787
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i7/118787.htm |
| DOI |
https://doi.org/10.4251/wjgo.118787 |
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