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Articles Published Processes
9/7/2026 2:26:33 AM | Browse: 0 | Download: 0
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Received |
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2026-01-12 06:28 |
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Peer-Review Started |
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2026-01-12 06:28 |
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First Decision by Editorial Office Director |
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2026-02-13 07:56 |
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Return for Revision |
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2026-02-13 07:56 |
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Revised |
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2026-03-09 04:28 |
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Publication Fee Transferred |
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2026-03-10 04:06 |
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Second Decision by Editor |
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2026-04-03 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-03 07:38 |
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Articles in Press |
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2026-04-03 07:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-16 08:29 |
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Publish the Manuscript Online |
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2026-09-07 02:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Specificity protein 1/ZIP8/zinc axis reduced macrophage extracellular traps to alleviate severe acute pancreatitis in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Miao Cheng, Qiong Liu, Zu-Xing Wei, Xiao-Yan Qi, Jun He and Xu-Yang Hou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hunan Province |
No. 2023JJ40821 |
| Natural Science Foundation of Changsha City |
No. kq2208308 |
| Hunan Provincial Health Commission Health Research Project |
No. W20243029 |
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| Corresponding Author |
Xu-Yang Hou, Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha 410011, Hunan Province, China. houxuyang@csu.edu.cn |
| Key Words |
Macrophage extracellular traps; Severe acute pancreatitis; Specificity protein 1; ZIP8; Zinc |
| Core Tip |
This study reveals that severe acute pancreatitis triggers macrophage extracellular trap (MET) formation in M1 macrophages through peptidylarginine deiminase 4 and reactive oxygen species pathways, linked to zinc deficiency and ZIP expression downregulation. Zinc supplementation and ZIP8 overexpression mitigate MET formation and organ injury. Additionally, specificity protein 1’s role in regulating ZIP8 expression is highlighted, with its downregulation exacerbating zinc deficiency and MET formation, offering novel insights into therapeutic strategies. |
| Publish Date |
2026-09-07 02:26 |
| Citation |
Cheng YM, Liu Q, Wei ZX, Qi XY, He J, Hou XY. Specificity protein 1/ZIP8/zinc axis reduced macrophage extracellular traps to alleviate severe acute pancreatitis in mice. World J Gastroenterol 2026; 32(38): 118814
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i38/118814.htm |
| DOI |
https://doi.org/10.3748/wjg.118814 |
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