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Articles Published Processes
6/12/2026 10:39:45 AM | Browse: 0 | Download: 0
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Received |
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2026-02-06 09:57 |
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Peer-Review Started |
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2026-02-06 09:57 |
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First Decision by Editorial Office Director |
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2026-02-25 03:04 |
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Return for Revision |
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2026-02-25 03:04 |
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Revised |
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2026-03-08 14:42 |
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Publication Fee Transferred |
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2026-03-13 09:35 |
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Second Decision by Editor |
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2026-04-13 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-13 07:25 |
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Articles in Press |
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2026-04-13 07:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-28 09:12 |
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Publish the Manuscript Online |
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2026-06-12 10:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Transmembrane emp24 domain-containing protein 4 regulates nuclear factor kappa-B/snail signaling to influence hepatocellular carcinoma cell behaviors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fa-Tao Hao and Zhi-Min Geng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Min Geng, MD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Yanta District, Xi’an 710061, Shaanxi Province, China. drgengzhimin@163.com |
| Key Words |
Hepatocellular carcinoma; Transmembrane emp24 domain-containing protein 4; Nuclear factor kappa-B/snail signaling pathway; Proliferation; Migration; Invasion |
| Core Tip |
Transmembrane emp24 domain-containing protein 4 (TMED4) was downregulated in hepatocellular carcinoma (HCC) SMMC-7721 cells compared with normal LO2 cells. Forced TMED4 overexpression significantly suppressed HCC cell proliferation, migration, and invasion. Mechanistically, TMED4 upregulated nuclear factor kappa-B (NF-κB) p65 while downregulating snail, indicating inhibition of malignant phenotypes through modulation of the NF-κB/snail signaling axis. These findings identify TMED4 as a potential regulator of HCC aggressiveness and a candidate molecular target for future therapeutic exploration. |
| Publish Date |
2026-06-12 10:39 |
| Citation |
Hao FT, Geng ZM. Transmembrane emp24 domain-containing protein 4 regulates nuclear factor kappa-B/snail signaling to influence hepatocellular carcinoma cell behaviors. World J Gastroenterol 2026; 32(24): 118822
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i24/118822.htm |
| DOI |
https://doi.org/10.3748/wjg.118822 |
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