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6/16/2026 8:10:09 AM | Browse: 0 | Download: 0
Publication Name World Journal of Experimental Medicine
Manuscript ID 118828
Country Türkiye
Received
2026-01-12 01:41
Peer-Review Started
2026-01-12 01:42
First Decision by Editorial Office Director
2026-02-26 07:30
Return for Revision
2026-02-26 07:30
Revised
2026-03-11 18:03
Publication Fee Transferred
Second Decision by Editor
2026-05-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-11 07:31
Articles in Press
2026-05-11 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-08 08:06
Publish the Manuscript Online
2026-06-16 08:10
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychology, Experimental
Manuscript Type Basic Study
Article Title Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury
Manuscript Source Invited Manuscript
All Author List Necmiye Şengel, Zeynep Köksal, Aysegül Küçük, Şaban Cem Sezen, Işın Güneş, Muharrem Atlı, Gülay Kip, Seda Gökgöz Acar, Abdullah Özer, Mustafa Kavutçu and Mustafa Arslan
ORCID
Author(s) ORCID Number
Necmiye Şengel http://orcid.org/0000-0001-8591-3658
Zeynep Köksal http://orcid.org/0000-0002-3601-9630
Aysegül Küçük http://orcid.org/0000-0001-9316-9574
Şaban Cem Sezen http://orcid.org/0000-0003-3996-7692
Muharrem Atlı http://orcid.org/0000-0002-2453-1370
Gülay Kip http://orcid.org/0000-0001-5242-5332
Seda Gökgöz Acar http://orcid.org/0000-0002-1901-1215
Abdullah Özer http://orcid.org/0000-0003-0925-7323
Mustafa Arslan http://orcid.org/0000-0003-4882-5063
Funding Agency and Grant Number
Corresponding Author Necmiye Şengel, Assistant Professor, Department of Oral and Maxillofacial Surgery, Gazi University Faculty of Dentistry, Bişkek Cd.(8.Cd.) 1.Sk. No:8 06490 Emek, Ankara 06490, Türkiye. necmiyesengel@hotmail.com
Key Words Spinal cord; Ischemia reperfusion; Liver; Lung; Brain; Ozone; Rat
Core Tip Spinal cord ischemia-reperfusion injury (IRI) is a complex process affecting multiple organs. Current preventive strategies remain insufficient. This study investigated the protective effects of single-dose ozone pretreatment via intrathecal, intraperitoneal, and rectal routes on liver, lung, and brain tissues in a rat spinal cord IRI model. Histopathological results demonstrated that ozone pretreatment through all three routes significantly reduced oxidative damage and improved tissue outcomes compared to the IR group. Medical ozone administration may offer a viable therapeutic option with high efficacy and minimal side effects in preventing IRI-related organ damage.
Publish Date 2026-06-16 08:10
Citation

Şengel N, Köksal Z, Küçük A, Sezen ŞC, Güneş I, Atlı M, Kip G, Gökgöz Acar S, Özer A, Kavutçu M, Arslan M. Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury. World J Exp Med 2026; 16(2): 118828

URL https://www.wjgnet.com/2220-315x/full/v16/i2/118828.htm
DOI https://doi.org/10.5493/wjem.118828
Full Article (PDF) WJEM-16-118828-with-cover.pdf
The ARRIVE Guidelines 118828-The-ARRIVE-Guidelines.pdf
Manuscript File 118828_Auto_Edited_061103.docx
Answering Reviewers 118828-answering-reviewers.pdf
Audio Core Tip 118828-audio.m4a
Biostatistics Review Certificate 118828-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 118828-conflict-of-interest-statement.pdf
Copyright License Agreement 118828-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 118828-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 118828-non-native-speakers.pdf
Peer-review Report 118828-peer-reviews.pdf
Scientific Misconduct Check 118828-scientific-misconduct-check.png
Scientific Editor Work List 118828-scientific-editor-work-list.pdf
CrossCheck Report 118828-crosscheck-report.pdf