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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 1204 | Download: 1442
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Received |
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2014-06-11 21:03 |
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Peer-Review Started |
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2014-06-12 11:08 |
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To Make the First Decision |
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2014-07-21 13:15 |
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Return for Revision |
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2014-07-22 15:22 |
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Revised |
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2014-07-31 11:37 |
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Second Decision |
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2014-11-11 10:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-11 10:22 |
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Articles in Press |
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2014-11-11 10:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-29 20:25 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Occult infection related hepatitis B surface antigen variants showing lowered secretion capacity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong Kim, Seoung-Ae Lee, You-Sub Won, HyunJoo Lee and Bum-Joon Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea grant funded by the Korean Government |
2013-005810 |
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| Corresponding Author |
Bum-Joon Kim, Professor, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr |
| Key Words |
Occult infection; Hepatitis B virus; Hepatitis B surface antigen; Variants; Genotype C; Reactive oxidative species |
| Core Tip |
The presently obtained data indicate that defi?ciency in the secretion capacity of hepatitis B surface antigen (HBsAg), but not virion, may have a pivotal function in occult infections of hepatitis B virus (HBV) genotype C, at least in occult infections in South Korea. This provided new insight into the intrinsic nature of HBV occult infections, which lead to HBsAg sero-negativeness but horizontal infectivity. In addition, reactive oxidative species production via possible induction of endoplasmic reticulum stress in hepatocytes provide a probable explanation for the links between occult infection and liver disease progression. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Kim H, Lee SA, Won YS, Lee HJ, Kim BJ. Occult infection related hepatitis B surface antigen variants showing lowered secretion capacity. World J Gastroenterol 2015; 21(6): 1794-1803 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1794.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1794 |
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