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Articles Published Processes
8/3/2026 1:24:00 AM | Browse: 2 | Download: 1
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Received |
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2026-01-13 06:08 |
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Peer-Review Started |
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2026-01-13 06:08 |
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First Decision by Editorial Office Director |
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2026-02-12 08:23 |
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Return for Revision |
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2026-02-12 08:23 |
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Revised |
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2026-02-13 22:01 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-03 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-03 06:49 |
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Articles in Press |
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2026-04-03 06:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-27 01:00 |
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Publish the Manuscript Online |
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2026-08-03 01:24 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sania El-Hindi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sania El-Hindi, Consultant, Doctorate Student, pediatric cardiology, Children's Hospital - Damascus University, Damascus, Syria, mazzeh, Damascus 011, Dimashq, Syria. saniahindi@yahoo.com |
| Key Words |
Persistent pulmonary; Hypertension of the newborn; Vardenafil; Sildenafil; Pulmonary vascular resistance; Phosphodiesterase inhibitors |
| Core Tip |
This is the first randomized controlled trial to evaluate the efficacy of vardenafil in the management of patients with persistent pulmonary hypertension of the newborn (PPHN). The study demonstrated that improvements in pulmonary hypertension, pulmonary vascular resistance, pulmonary artery flow velocity, and respiratory distress were faster in the vardenafil group than in sildenafil group without adverse events. These findings if confirmed in larger clinical trials may position vardenafil as a preferred first-line therapy for PPHN particularly in resource limited settings. |
| Publish Date |
2026-08-03 01:24 |
| Citation |
El-Hindi S. Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn. World J Clin Pediatr 2026; 15(3): 118862
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i3/118862.htm |
| DOI |
https://doi.org/10.5409/wjcp.118862 |
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