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Articles Published Processes
6/30/2026 1:40:18 PM | Browse: 0 | Download: 0
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Received |
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2026-01-22 00:49 |
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Peer-Review Started |
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2026-01-22 00:49 |
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First Decision by Editorial Office Director |
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2026-02-02 09:19 |
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Return for Revision |
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2026-02-02 09:19 |
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Revised |
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2026-02-26 21:37 |
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Publication Fee Transferred |
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2026-03-04 14:44 |
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Second Decision by Editor |
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2026-03-17 03:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-17 09:24 |
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Articles in Press |
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2026-03-17 09:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-12 04:52 |
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Publish the Manuscript Online |
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2026-06-30 13:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Chang, Rong Sun, Wei Juan, Zheng Xu, Hao-Yu Xu, Ke Zen and Ji Xuan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ji Xuan, Department of Gastroenterology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Zhongshan East Road 305, Nanjing 210002, Jiangsu Province, China., Nanjing 210002, Jiangsu Province, China. xuanji@nju.edu.cn |
| Key Words |
Chronic radiation proctitis; Endoscopic views; Endoscopic scoring; Tubulin; Rat model |
| Core Tip |
Chronic radiation proctitis can be induced by a single dose of 20-35 Gy irradiation, which simplifies the modeling procedure while recapitulating two major human pathological features: Telangiectasia and progressive fibrosis. The formation of chronic injury is associated with the destruction of microtubule protein, the low expression of tubulin at 2 weeks after irradiation can serve as an early indicator for the transition of rectal toward chronic radiation injury. After radiation without intervention, around the eighth week, chronic manifestations such as capillary dilation would appear. The observation period for the therapeutic effect should be extended to at least 8 weeks. |
| Publish Date |
2026-06-30 13:40 |
| Citation |
Chang Y, Sun R, Juan W, Xu Z, Xu HY, Zen K, Xuan J. Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin. World J Gastroenterol 2026; 32(26): 118923
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i26/118923.htm |
| DOI |
https://doi.org/10.3748/wjg.v32.i26.118923 |
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