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Articles Published Processes
6/11/2026 11:23:59 AM | Browse: 0 | Download: 0
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Received |
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2026-01-15 02:52 |
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Peer-Review Started |
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2026-01-26 00:42 |
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First Decision by Editorial Office Director |
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2026-02-28 06:44 |
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Return for Revision |
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2026-02-28 06:44 |
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Revised |
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2026-03-17 04:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-11 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-11 06:53 |
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Articles in Press |
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2026-05-11 06:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-27 09:14 |
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Publish the Manuscript Online |
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2026-06-11 11:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Opinion Review |
| Article Title |
Gut microbiota: Unseen conductor of polyherbal efficacy in diabetic neuropathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Si Chen, Yu-Xiang Liu, Zhi-Bo Zhao, Shu-Qin Tang, Jun-Hu Li and Xiao-Shuang Zhou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82300846 |
| Project of the Central Government Guiding Local Technological Development |
No. YDZJSX2025B007 |
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| Corresponding Author |
Xiao-Shuang Zhou, Department of Nephrology, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Provincial People’s Hospital, No. 29 Shuangta Temple Street, Yingze District, Taiyuan 030012, Shanxi Province, China. xiaoshuangzhou69@163.com |
| Key Words |
Diabetic neuropathy; Gut microbiota; Polyherbal formulation; Prebiotics; Short-chain fatty acids; Inflammation; Traditional medicine |
| Core Tip |
This review proposes a gut-centric theoretical model to explain the broad therapeutic effects of a polyherbal extract (PHE) against diabetic neuropathy. We hypothesize that the PHE acts primarily by remodeling the gut microbiota. This single action restoring a healthy gut ecosystem can mechanistically account for the observed systemic reductions in inflammation, oxidative stress, and metabolic dysfunction. This perspective reframes traditional herbal medicine as a form of ecological intervention, highlighting the gut microbiome as a pivotal and unifying target for treating complex, multi-system diseases. |
| Publish Date |
2026-06-11 11:23 |
| Citation |
Chen S, Liu YX, Zhao ZB, Tang SQ, Li JH, Zhou XS. Gut microbiota: Unseen conductor of polyherbal efficacy in diabetic neuropathy. World J Diabetes 2026; 17(6): 118936
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i6/118936.htm |
| DOI |
https://doi.org/10.4239/wjd.118936 |
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