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Articles Published Processes
7/14/2026 9:34:57 AM | Browse: 2 | Download: 0
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Received |
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2026-02-03 09:54 |
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Peer-Review Started |
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2026-02-03 09:54 |
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First Decision by Editorial Office Director |
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2026-02-25 03:03 |
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Return for Revision |
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2026-02-25 03:03 |
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Revised |
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2026-03-10 06:59 |
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Publication Fee Transferred |
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2026-03-16 06:55 |
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Second Decision by Editor |
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2026-03-27 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-27 08:18 |
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Articles in Press |
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2026-03-27 08:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-25 08:29 |
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Publish the Manuscript Online |
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2026-07-14 09:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 drives immunosuppression in gastric cancer by suppressing dendritic cell maturation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yang-Yang Liu, Jun-Hua Ai, Le-Ming Zeng, Xue-Ni Liu and Fang Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General Project Funded by Jiangxi Provincial Natural Science Foundation |
No. 20232BAB206095 |
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| Corresponding Author |
Fang Wu, Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. wf70601852@163.com |
| Key Words |
Gastric cancer; Exosomal indoleamine 2,3 dioxygenase 1; Dendritic cells; Cytotoxic T cells; Immunosuppression |
| Core Tip |
Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 (IDO1) suppresses dendritic cell (DC) maturation, thereby facilitating tumor immune evasion. This study demonstrates that IDO1 is upregulated in gastric cancer tissues and selectively enriched in tumor-derived exosomes. These IDO1-carrying exosomes are internalized by DCs, leading to downregulation of maturation markers [cluster of differentiation (CD) 80, CD86, major histocompatibility complex class II] and an immunosuppressive cytokine shift [decreased interleukin (IL)-12p70 (IL-12p70), increased IL-10]. Silencing IDO1 in exosomes reverses these effects and attenuates tumor growth in vivo. Our findings identify exosomal IDO1 as a key mediator of tumor-DC crosstalk and a promising therapeutic target in gastric cancer. |
| Publish Date |
2026-07-14 09:34 |
| Citation |
Liu YY, Ai JH, Zeng LM, Liu XN, Wu F. Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 drives immunosuppression in gastric cancer by suppressing dendritic cell maturation. World J Gastroenterol 2026; 32(28): 118939
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i28/118939.htm |
| DOI |
https://doi.org/10.3748/wjg.118939 |
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