| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrated diagnostic model based on serum exosomal microRNAs and functional mechanism of miR-200b-3p in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Ye Sun, Na Fu, Dan-Dan Zhao, Zheng-Lu Wang, Lei Cao, Jia-Li Qiu, Yi Li, Wei Gao, Jin-Liang Duan, Lin Li and Yue-Min Nan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Research and Development Program of Hebei Province-Biomedical Innovation Project |
23377705D |
| Introduction of Foreign Intelligence Program in Hebei Province in 2024 |
|
|
| Corresponding Author |
Yue-Min Nan, Chief, MD, PhD, Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang 050051, Hebei Province, China. nanyuemin@hebmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Exosomal microRNAs; Diagnostic model; MicroRNA-200b-3p; Phosphoserine aminotransferase 1; Liquid biopsy |
| Core Tip |
This study developed and validated a novel three-exosomal-miRNA (miR-200b-3p, miR-215-5p, miR-452-5p) and age-based diagnostic model for hepatocellular carcinoma (HCC) using a rigorous multi-cohort design. The model demonstrated high accuracy with an area under the curve of 0.863, offering a robust non-invasive tool for early detection. Furthermore, we experimentally identified phosphoserine aminotransferase 1 as a direct functional target of miR-200b-3p, establishing its tumor-suppressive role in HCC. Our work provides both a clinically promising liquid biopsy biomarker panel and a key mechanistic insight, advancing the field of precision diagnosis for HCC. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Sun XY, Fu N, Zhao DD, Wang ZL, Cao L, Qiu JL, Li Y, Gao W, Duan JL, Li L, Nan YM. Integrated diagnostic model based on serum exosomal microRNAs and functional mechanism of miR-200b-3p in hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(9): 118948
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/118948.htm |
| DOI |
https://doi.org/10.4251/wjgo.118948 |
