Publication Name	World Journal of Experimental Medicine
Manuscript ID	11897
Country	Canada

Received	2014-06-11 08:13
Peer-Review Started	2014-06-11 16:53
To Make the First Decision	2014-07-10 17:21
Return for Revision	2014-07-11 16:41
Revised	2014-07-16 03:03
Second Decision	2014-09-10 13:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-10 13:56
Articles in Press	2014-09-10 13:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-06 08:25
Publish the Manuscript Online	2014-11-19 14:49

ISSN	2220-315x (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Combinations of vascular endothelial growth factor pathway inhibitors with metronomic chemotherapy: Rational and current status
Manuscript Source	Invited Manuscript
All Author List	Antonia Digklia and Ioannis A Voutsadakis
Funding Agency and Grant Number
Corresponding Author	Ioannis A Voutsadakis, MD, PhD, Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Sainte Marie, Ontario, Canada and Division of Clinical Sciences, Northern Ontario School of Medicine, 750 Great Northern Road, Sault Ste Marie, ON P6B 0A8, Canada. ivoutsadakis@yahoo.com or
Key Words	Metronomic chemotherapy; Vascular endothelial growth factor; Angiogenesis; Bevacizumab; Vascular endothelial growth factor receptor
Core Tip	Metronomic chemotherapy has the potential to reduce the toxicity of chemotherapy administered with conventional schedules. In addition, understanding of the importance of angiogenesis in the mechanism of action of metronomic schedules provides a rational to combine this type of administration with targeted agents against the vascular endothelial growth factor signaling pathway.
Publish Date	2014-11-19 14:49
Citation	Digklia A, Voutsadakis IA. Combinations of vascular endothelial growth factor pathway inhibitors with metronomic chemotherapy: Rational and current status. World J Exp Med 2014; 4(4): 58-67
URL	http://www.wjgnet.com/2220-315X/full/v4/i4/58.htm
DOI	http://dx.doi.org/10.5493/wjem.v4.i4.58

Full Article (PDF)	WJEM-4-58.pdf
Full Article (Word)	WJEM-4-58.doc
Manuscript File	11897-Review.doc
Answering Reviewers	11897-Answering reviewers.pdf
Copyright License Agreement	11897-Copyright assignment.pdf
Peer-review Report	11897-Peer review(s).pdf
Scientific Misconduct Check	11897-CrossCheck.jpg
Scientific Editor Work List	11897-Scientific editor work list.pdf