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Articles Published Processes
6/9/2026 9:23:52 AM | Browse: 0 | Download: 0
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Received |
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2026-01-16 06:06 |
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Peer-Review Started |
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2026-01-16 06:16 |
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First Decision by Editorial Office Director |
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2026-01-29 09:22 |
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Return for Revision |
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2026-01-29 09:26 |
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Revised |
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2026-02-04 04:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-11 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-11 06:05 |
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Articles in Press |
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2026-02-11 06:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-26 09:35 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Cryoablation remodels the immune microenvironment in hepatocellular carcinoma: From mechanistic insights to clinical translation in combination immunotherapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Ju Xu, Chun-Xiao Ni, Li-Dong Qin, Ping Wang and Jia-Ju Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Scientific Research Fund of Tai’an Science and Technology Agency |
2019NS180 |
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| Corresponding Author |
Jia-Ju Xu, MD, Department of Medical Oncology, Tai’an City Central Hospital, Tai’an City Central Hospital, Tai’an, No. 29, Longtan Road, Shandong, China., Tai’an 271000, Shandong Province, China. jiajuxu1101@163.com |
| Key Words |
Hepatocellular carcinoma; Cryoablation; Tumor microenvironment; Immunotherapy; Immunogenic cell death; Combination therapy |
| Core Tip |
Cryoablation exerts a dual and exploitable immunomodulatory effects in hepatocellular carcinoma. Acting as an in situ vaccine, cryoablation induces immunogenic cell death and simultaneously triggers a transient immunosuppressive effect. This duality is strategically used by combining cryoablation with immune checkpoint inhibitors to remodel the immunosuppressive “cold” tumor microenvironment. Ablation completeness, technical parameters, and host immune status are critical determinants of therapeutic success. In order to fully achieve its clinical potential, future initiatives ought to be directed towards overcoming the difficulties of patient stratification and treatment sequencing by developing predictive biomarkers and optimized combination regimens. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Xu JJ, Ni CX, Qin LD, Wang P, Xu JJ. Cryoablation remodels the immune microenvironment in hepatocellular carcinoma: From mechanistic insights to clinical translation in combination immunotherapy. World J Gastrointest Oncol 2026; 18(6): 118976
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/118976.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.118976 |
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