Publication Name	World Journal of Gastroenterology
Manuscript ID	11901
Country	Japan

Received	2014-06-11 13:43
Peer-Review Started	2014-06-11 15:38
To Make the First Decision	2014-07-09 12:01
Return for Revision	2014-07-15 10:58
Revised	2014-07-18 21:50
Second Decision	2014-09-16 13:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-16 13:51
Articles in Press	2014-09-16 13:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-03 17:42
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Alternative splicing of DNA damage response genes and gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Bahityar Rahmutulla, Kazuyuki Matsushita and Fumio Nomura
Funding Agency and Grant Number
Corresponding Author	Kazuyuki Matsushita, MD, PhD, Associate Professor, Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. kmatsu@faculty.chiba-u.jp
Key Words	Alternative splicing; DNA damage; Gastrointestinal cancer; Mutation; Genetic instability
Core Tip	Alternative splicing is a fundamental process of gene regulation in eukaryotes. Alternative splicing of DNA damage repair proteins is a significant cause of gene mutations, and those mutations in turn affect alternative splicing in cancer. Alternative splicing is associated with tumorigenesis by contributing to genetic instability. Therefore, alternative splicing of DNA damage response-related genes has an important role in tumorigenesis, survival, and growth of gastrointestinal cancers. In summary, the alternative splicing variants of these genes could be potential targets for both diagnosis and treatment of gastrointestinal cancers.
Publish Date	2014-12-18 17:08
Citation	Rahmutulla B, Matsushita K, Nomura F. Alternative splicing of DNA damage response genes and gastrointestinal cancers. World J Gastroenterol 2014; 20(46): 17305-17313
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17305.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17305

Full Article (PDF)	WJG-20-17305.pdf
Full Article (Word)	WJG-20-17305.doc
Manuscript File	11901-Review.docx
Answering Reviewers	11901-Answering reviewers.pdf
Copyright License Agreement	11901-Copyright assignment.pdf
Peer-review Report	11901-Peer reviews.pdf
Scientific Misconduct Check	11901-CrossCheck.jpg
Scientific Editor Work List	11901-Scientific editor work list.pdf