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Articles Published Processes
8/7/2026 9:40:25 AM | Browse: 1 | Download: 0
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Received |
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2026-02-06 10:06 |
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Peer-Review Started |
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2026-02-06 10:06 |
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First Decision by Editorial Office Director |
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2026-02-25 02:53 |
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Return for Revision |
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2026-02-25 02:53 |
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Revised |
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2026-03-11 09:39 |
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Publication Fee Transferred |
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2026-03-23 09:03 |
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Second Decision by Editor |
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2026-06-22 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-22 07:53 |
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Articles in Press |
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2026-06-22 07:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-17 00:29 |
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Publish the Manuscript Online |
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2026-08-07 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Biao Huang, Bai-Song Chen, Ai-Ping Wang, Xiu-Zhen Hu and Ye-Jin Xu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ye-Jin Xu, Chief Physician, Departmeng of Infectious Diseases, Jinhua Municipal Central Hospital, No. 365 Renmin East Road, Jinhua 321000, Zhejiang Province, China. xuyejinfox@163.com |
| Key Words |
Streptococcus anginosus; Polymerase chain reaction; Digestive tract neoplasms; Gastric cancer; Interleukin-6; Tumor necrosis factor-α; Immune cell infiltration |
| Core Tip |
This study characterizes Streptococcus anginosus (S. anginosus) colonization across digestive diseases and its immunomodulatory role in gastric cancer. In a prospective cohort of 93 patients, S. anginosus positivity and relative load were highest in malignant tumors. Using a chemically induced gastric cancer rat model, S. anginosus colonization was shown to promote tumor progression, elevate serum interleukin-6 and tumor necrosis factor-α levels, and enhance infiltration of CD4+, CD8+ T cells, and CD68+ macrophages. The findings indicate that S. anginosus remodels the tumor immune microenvironment to favor carcinogenesis, suggesting its potential as a microbial and immunotherapeutic target. |
| Publish Date |
2026-08-07 09:40 |
| Citation |
Huang DB, Chen BS, Wang AP, Hu XZ, Xu YJ. Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model. World J Gastrointest Oncol 2026; 18(8): 119026
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i8/119026.htm |
| DOI |
https://doi.org/10.4251/wjgo.119026 |
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