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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 119040
Country China
Received
2026-01-21 06:40
Peer-Review Started
2026-01-21 06:41
First Decision by Editorial Office Director
2026-01-27 07:56
Return for Revision
2026-01-27 11:39
Revised
2026-02-09 08:13
Publication Fee Transferred
2026-02-14 16:01
Second Decision by Editor
2026-04-14 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-04-14 03:57
Articles in Press
2026-04-14 03:57
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-17 07:15
Publish the Manuscript Online
2026-07-13 09:40
ISSN 1948-5204 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Prognostic factors and optimal timing for initiating adjuvant chemotherapy in stage IIIC gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Jun-Wei Wu, Fan Li, Shi-Dian Wang, Yu-Kun Guo, Bing-Huang Li, Xin Zhou, Guo-Qiang Su and Chuan-Hui Lu
ORCID
Author(s) ORCID Number
Jun-Wei Wu http://orcid.org/0009-0000-3405-3897
Chuan-Hui Lu http://orcid.org/0009-0007-8307-5903
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 81970462
Key Medical and Health Project of Xiamen No. 3502Z20204001
Corresponding Author Chuan-Hui Lu, /, The Graduate School of Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou 350122, Fujian Province, China. 46601533@qq.com
Key Words Gastric cancer; Chemotherapy; Disease-free survival; Prognosis; Time factors
Core Tip We identified age ≥ 60 years, carcinoembryonic antigen ≥ 5.0 μg/L, metastatic lymph node ratio ≥ 0.5 and time interval (TI) from surgery to initiation of adjuvant chemotherapy are independent risk factors for postoperative recurrence. Crucially, our findings demonstrate that initiating adjuvant chemotherapy within 6 weeks of surgery significantly improves disease-free survival in stage IIIC patients. Notably, the S-1 plus oxaliplatin regimen exhibits significant time-sensitivity, with an optimal window of within 6 weeks. Whereas the capecitabine plus oxaliplatin regimen does not. These insights provide a rationale for optimizing individualized therapeutic strategies for this high-risk subgroup.
Publish Date 2026-07-13 09:40
Citation

Wu JW, Li F, Wang SD, Guo YK, Li BH, Zhou X, Su GQ, Lu CH. Prognostic factors and optimal timing for initiating adjuvant chemotherapy in stage IIIC gastric cancer. World J Gastrointest Oncol 2026; 18(7): 119040

URL https://www.wjgnet.com/1948-5204/full/v18/i7/119040.htm
DOI https://doi.org/10.4251/wjgo.v18.i7.119040
Full Article (PDF) WJGO-18-119040-with-cover.pdf
STROBE Statement 119040-STROBE-statement.pdf
Manuscript File 119040_Auto_Edited_071306.docx
Answering Reviewers 119040-answering-reviewers.pdf
Audio Core Tip 119040-audio.wav
Biostatistics Review Certificate 119040-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 119040-conflict-of-interest-statement.pdf
Copyright License Agreement 119040-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119040-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119040-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 119040-non-native-speakers.pdf
Peer-review Report 119040-peer-reviews.pdf
Scientific Misconduct Check 119040-scientific-misconduct-check.png
Scientific Editor Work List 119040-scientific-editor-work-list.pdf
CrossCheck Report 119040-crosscheck-report.pdf