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Articles Published Processes
6/9/2026 9:23:53 AM | Browse: 0 | Download: 0
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Received |
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2026-01-21 05:50 |
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Peer-Review Started |
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2026-01-21 05:51 |
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First Decision by Editorial Office Director |
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2026-02-04 08:19 |
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Return for Revision |
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2026-02-04 08:19 |
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Revised |
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2026-02-05 10:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-05 02:53 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-05 10:14 |
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Articles in Press |
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2026-03-05 10:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-07 10:22 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Evolving landscape of the gastric cancer immune microenvironment: From spatial architecture to precision biomarkers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhi-Yuan Yao, Li-Jie Ma, Zheng-Xiang Han and Gui-Juan Ji |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gui-Juan Ji, PhD, Professor, Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221000, Jiangsu Province, China. 190621642@qq.com |
| Key Words |
Gastric cancer; Biomarkers; Tumor immune microenvironment; Tertiary lymphoid structures; Immune checkpoint inhibitors |
| Core Tip |
Gastric cancer therapy must evolve beyond traditional approaches by focusing on the tumor immune microenvironment, which is shaped by spatial architecture, metabolic reprogramming, and microbiota interactions. The reliance on static biomarkers like programmed death-ligand 1 expression is shifting towards dynamic markers, such as tertiary lymphoid structure and circulating tumor DNA, to better predict treatment outcomes. A shift towards “ecosystem engineering” strategies, including vascular normalization, stromal reprogramming, and combination therapies like antibody-drug conjugates and chimeric antigen receptor T cells, is crucial for overcoming immune evasion and improving patient responses. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Yao ZY, Ma LJ, Han ZX, Ji GJ. Evolving landscape of the gastric cancer immune microenvironment: From spatial architecture to precision biomarkers. World J Gastrointest Oncol 2026; 18(6): 119114
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/119114.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.119114 |
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