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Articles Published Processes
6/25/2026 8:21:20 AM | Browse: 0 | Download: 0
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Received |
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2026-01-20 07:17 |
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Peer-Review Started |
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2026-01-20 08:28 |
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First Decision by Editorial Office Director |
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2026-02-10 09:20 |
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Return for Revision |
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2026-02-10 09:20 |
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Revised |
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2026-02-21 09:47 |
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Publication Fee Transferred |
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2026-02-26 05:50 |
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Second Decision by Editor |
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2026-03-26 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-02 06:25 |
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Articles in Press |
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2026-04-02 06:25 |
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Edit the Manuscript by Language Editor |
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2026-04-07 03:45 |
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Typeset the Manuscript |
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2026-06-12 14:04 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Selenoprotein P attenuates oxidative senescence and ferroptosis-associated lipid peroxidation in dental pulp stem cells through a FOXM1-dependent program
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ruo-Qi Zhang, Wei-Hao Chu, Jun-Bo Bai, Yong-Hua Lei and Dai Zhou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82201771 |
| Natural Science Foundation of Hunan Province |
2024JJ6083 |
| Health Research Project of Hunan Provincial Health Commission |
W20243143 |
| Natural Science Foundation of Changsha |
kq2202491 |
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| Corresponding Author |
Dai Zhou, Full Professor, PhD, Post Doctoral Researcher, Changsha Hospital for Maternal and Child Health Care, Hunan Normal University, No. 416 Chengnan Road, Changsha 410000, Hunan Province, China. zhoudai@hunnu.edu.cn |
| Key Words |
Dental pulp stem cells; Aging; Selenoprotein P; Selenium; Oxidative stress; Ferroptosis; Forkhead box protein M1 |
| Core Tip |
Aging-associated decline of dental pulp stem cells is linked to impaired selenium-dependent antioxidant defense. This study integrates single-cell transcriptomics, oxidative stress modeling, and human tissue validation to show that selenoprotein P and sodium selenite co-treatment reduces senescence and ferroptosis-associated lipid peroxidation in dental pulp stem cells. The combined treatment is more effective than either agent alone, and ferrostatin-1 rescue supports ferroptosis-related injury involvement. Transcriptomic and knockdown analyses identify a forkhead box protein M1-dependent protective program downstream of selenoprotein P/selenium support, highlighting a candidate strategy for preserving dental pulp vitality during aging. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Zhang RQ, Chu WH, Bai JB, Lei YH, Zhou D. Selenoprotein P attenuates oxidative senescence and ferroptosis-associated lipid peroxidation in dental pulp stem cells through a FOXM1-dependent program. World J Stem Cells 2026; 18(6): 119118
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/119118.htm |
| DOI |
https://doi.org/10.4252/wjsc.119118 |
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