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Articles Published Processes
11/12/2026 3:43:53 AM | Browse: 3 | Download: 113
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Received |
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2026-01-20 01:45 |
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Peer-Review Started |
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2026-01-20 01:51 |
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First Decision by Editorial Office Director |
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2026-01-29 08:06 |
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Return for Revision |
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2026-01-29 08:06 |
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Revised |
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2026-01-30 08:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-02 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-02 03:54 |
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Articles in Press |
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2026-03-02 03:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-01 04:15 |
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Publish the Manuscript Online |
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2026-11-12 03:43 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Preoperative depression as a neuroimmune-cholinergic vulnerability state for postoperative cognitive dysfunction after gastrointestinal cancer surgery
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gang Wang and Sheng-Jie Pan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gang Wang, MD, PhD, Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. 286651551@qq.com |
| Key Words |
Postoperative cognitive dysfunction; Preoperative depression; Gastrointestinal tumor surgery; Cholinergic dysfunction; Neuroinflammation; Interleukin-6; Perioperative brain health |
| Core Tip |
Postoperative cognitive dysfunction (POCD) is a frequent yet underappreciated complication in elderly patients undergoing gastrointestinal tumor surgery. This editorial highlight emerging evidence that preoperative depression represents a biologically active vulnerability state that predisposes patients to POCD through synergistic neuroinflammatory activation and cholinergic dysfunction. By integrating findings on interleukin-6-mediated inflammation and impaired cholinergic regulation, the article reframes POCD as a disorder of perioperative brain resilience. This perspective supports earlier risk identification and mechanism-based preventive strategies to preserve cognitive health in aging surgical populations. |
| Publish Date |
2026-11-12 03:43 |
| Citation |
Wang G, Pan SJ. Preoperative depression as a neuroimmune-cholinergic vulnerability state for postoperative cognitive dysfunction after gastrointestinal cancer surgery. World J Gastrointest Surg 2026; 18(11): 119120
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| URL |
https://www.wjgnet.com/1948-9366/full/v18/i11/119120.htm |
| DOI |
https://doi.org/10.4240/wjgs.119120 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
