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Articles Published Processes
6/9/2026 9:23:55 AM | Browse: 0 | Download: 0
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Received |
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2026-01-20 07:01 |
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Peer-Review Started |
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2026-01-20 07:02 |
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First Decision by Editorial Office Director |
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2026-01-28 08:00 |
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Return for Revision |
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2026-01-28 08:00 |
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Revised |
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2026-02-10 11:48 |
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Publication Fee Transferred |
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2026-02-15 06:26 |
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Second Decision by Editor |
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2026-03-12 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-12 07:20 |
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Articles in Press |
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2026-03-12 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-24 05:29 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Premna microphylla Turcz. reshapes nutritional metabolism via the Simulator of the Human Intestinal Microbial Ecosystem model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Di Zhu, Chang Xu, Sheng-Hong Guan, Yu-Ming Lou, Kan-Kai Zhu, Run-Feng Lin, Hai-Long Jin, Shuo Chai, Xiao-Yong Zhang, Xiao-Sun Liu and Jing-Kui Tian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Joint Traditional Chinese Medicine Science & Technology Projects of National Demonstration Zones for Comprehensive Traditional Chinese Medicine Reform |
ZY-KJS-ZJ-2025-052 |
| Joint Traditional Chinese Medicine Science & Technology Projects of National Demonstration Zones for Comprehensive Traditional Chinese Medicine Reform |
GZY-KJS-ZJ-2025-036 |
| Key Research & Development Plan of Zhejiang Province |
2025C02171 |
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| Corresponding Author |
Xiao-Sun Liu, Professor, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 366, Wutong Road, Hangzhou 310000, Zhejiang Province, China. xiaosunliu@zju.edu.cn |
| Key Words |
Gastric cancer; Chemotherapy combined with immunotherapy; Nutritional bioactivity; Simulator of the Human Intestinal Microbial Ecosystem; Premna microphylla Turcz |
| Core Tip |
This study established an intestinal microbial ecosystem (Simulator of the Human Intestinal Microbial Ecosystem) model to uncover the differential absorption and metabolism profiles of Premna microphylla Turcz. (PMT) across various intestinal segments. We demonstrated that chemotherapy-induced gut microbiota dysbiosis leads to a shift in the primary absorption site of active ingredients toward the colon. These findings not only provide a scientific basis for developing novel strategies to improve cancer patient prognosis but also lay a solid theoretical foundation for utilizing PMT as a low-toxicity therapeutic agent. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Zhu HD, Xu C, Guan SH, Lou YM, Zhu KK, Lin RF, Jin HL, Chai S, Zhang XY, Liu XS, Tian JK. Premna microphylla Turcz. reshapes nutritional metabolism via the Simulator of the Human Intestinal Microbial Ecosystem model. World J Gastrointest Oncol 2026; 18(6): 119130
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/119130.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.119130 |
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