Publication Name	World Journal of Gastroenterology
Manuscript ID	11915
Country	China

Received	2014-06-12 09:51
Peer-Review Started	2014-06-12 09:55
To Make the First Decision	2014-06-27 17:32
Return for Revision	2014-07-02 17:37
Revised	2014-07-09 11:06
Second Decision	2014-08-28 10:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-08-28 10:38
Articles in Press	2014-08-28 10:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-11 03:01
Typeset the Manuscript	2014-11-07 19:11
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Phosphatidylinositol 3-kinase CB is associated with response to preoperative radiotherapy for rectal adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Dong Yu, Yi-Fan Peng, Hong-Da Pan, Lin Wang, Kun Li and Jin Gu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30872923 Peking University People’s Hospital Research and Development Fund RDB2007-47 Peking University People’s Hospital Research and Development Fund RDK2008-01 Peking University People’s Hospital Research and Development Fund RDB2011-25
Corresponding Author	Jin Gu, MD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Colorectal Surgery, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China. zlgujin@qq.com
Key Words	Phosphatidylinositol 3-kinase CB; Tumor regression grade; ypT stage; Disease-free survival; Therapeutic target; Rectal cancer; Preoperative radiotherapy
Core Tip	The response of rectal cancer cells to preoperative radiotherapy may have been due to dysregulation of phosphatidylinositol 3-kinase (PI3K) signaling molecules, in particular, high expression of PIK3CB. Therefore, we evaluated whether this upregulation was involved in the poor response to preoperative radiotherapy in patients with rectal adenocarcinoma. We found that high expression of PIK3CB was involved in poor response to preoperative radiotherapy, and associated with adverse outcomes in rectal adenocarcinoma patients treated with 30-Gy/10-fraction preoperative radiotherapy. Using PIK3CB-specific inhibitor TGX-221, we showed that inhibition of PIK3CB expression enhanced the response to radiotherapy.
Publish Date	2014-11-20 20:51
Citation	Yu WD, Peng YF, Pan HD, Wang L, Li K, Gu J. Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. World J Gastroenterol 2014; 20(43): 16258-16267
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16258.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16258

Full Article (PDF)	WJG-20-16258.pdf
Full Article (Word)	WJG-20-16258.doc
Manuscript File	11915-Review.doc
Answering Reviewers	11915-Answering reviewers.pdf
Copyright License Agreement	11915-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11915-Language certificate.PDF
Peer-review Report	11915-Peer review.pdf
Scientific Misconduct Check	11915-CorssCheck.jpg
Scientific Editor Work List	11915-Scientific editor work list.pdf