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Articles Published Processes
5/20/2026 8:53:14 AM | Browse: 1 | Download: 0
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Received |
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2026-01-20 00:58 |
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Peer-Review Started |
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2026-01-20 00:58 |
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First Decision by Editorial Office Director |
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2026-01-28 08:42 |
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Return for Revision |
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2026-01-28 08:42 |
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Revised |
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2026-02-06 00:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-13 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-13 04:11 |
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Articles in Press |
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2026-03-13 04:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-30 14:08 |
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Publish the Manuscript Online |
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2026-05-20 08:53 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Immunomodulatory and antitumor effects of shilajit and glycine: Natural metabolic modulators targeting breast and liver cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tasneem A Basbrain, Nidal M Zabermawi, Jehan S Alrahimi and Kawther A Zaher |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kawther A Zaher, Professor, Department of Immunology Unit, King Fahd Medical Research Center, and Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Gamaa Road, Jeddah 21589, Saudi Arabia. kzaher@kau.edu.sa |
| Key Words |
Shilajit; Glycine; Immunometabolism; One-carbon metabolism; Tumor microenvironment; Breast cancer; Hepatocellular carcinoma; Natural products |
| Core Tip |
Shilajit and glycine are low-cost natural agents with convergent immunometabolic activity relevant to breast cancer and hepatocellular carcinoma. This minireview summarizes how shilajit fractions and glycine-dependent redox and one-carbon pathways may modulate oxidative stress, inflammatory signaling, and immune-cell polarization within the tumor microenvironment. We highlight practical translational priorities, including extract standardization, pharmacokinetic constraints, biomarker-guided patient stratification, and rational combinations with established anticancer therapies. |
| Publish Date |
2026-05-20 08:53 |
| Citation |
Basbrain TA, Zabermawi NM, Alrahimi JS, Zaher KA. Immunomodulatory and antitumor effects of shilajit and glycine: Natural metabolic modulators targeting breast and liver cancer. World J Clin Oncol 2026; 17(5): 119163 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i5/119163.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i5.119163 |
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