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Articles Published Processes
8/5/2026 7:53:16 AM | Browse: 0 | Download: 0
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Received |
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2026-01-21 00:25 |
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Peer-Review Started |
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2026-01-29 09:15 |
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First Decision by Editorial Office Director |
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2026-03-04 08:54 |
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Return for Revision |
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2026-03-04 08:54 |
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Revised |
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2026-05-22 11:16 |
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Publication Fee Transferred |
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2026-06-11 01:55 |
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Second Decision by Editor |
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2026-07-14 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-14 08:14 |
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Articles in Press |
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2026-07-14 08:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-28 00:26 |
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Publish the Manuscript Online |
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2026-08-05 07:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Severe insulin-deficient diabetes: Updated review of epidemiology, biology, and clinical implications
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yara S Beyh, K M Venkat Narayan and Ram Jagannathan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Heart, Lung, and Blood Institute |
No. P01HL154996 |
| National Institute of Diabetes and Digestive and Kidney Diseases |
No. R01-DK139632 |
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| Corresponding Author |
Yara S Beyh, PhD, Post Doctoral Researcher, Postdoc, Postdoctoral Fellow, Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, United States. ybeyh@emory.edu |
| Key Words |
Type 2 diabetes; Severe insulin-deficient diabetes; Insulin deficiency; Insulin resistance; Beta-cell function |
| Core Tip |
Severe insulin-deficient diabetes (SIDD) is a reproducible, non-autoimmune subtype of type 2 diabetes defined by profound β-cell dysfunction, marked hyperglycemia, and relatively lower body mass index. This review synthesizes global evidence showing that SIDD carries disproportionate microvascular risk particularly retinopathy and often requires early treatment intensification with frequent insulin use. A key innovation is highlighting population-specific subtype distributions, with insulin-deficient phenotypes more common in South Asians and linked to emerging signals for higher mortality and excess life-years lost. We integrate genetic and multi-omic insights implicating β-cell stress pathways and outline priorities for electronic health record-ready classification and subtype-guided trials. |
| Publish Date |
2026-08-05 07:53 |
| Citation |
Beyh YS, Narayan KMV, Jagannathan R. Severe insulin-deficient diabetes: Updated review of epidemiology, biology, and clinical implications. World J Diabetes 2026; 17(8): 119203
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i8/119203.htm |
| DOI |
https://doi.org/10.4239/wjd.119203 |
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