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Articles Published Processes
5/25/2026 7:47:56 AM | Browse: 0 | Download: 0
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Received |
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2026-01-22 02:50 |
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Peer-Review Started |
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2026-01-22 02:53 |
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First Decision by Editorial Office Director |
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2026-01-30 08:59 |
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Return for Revision |
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2026-01-30 08:59 |
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Revised |
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2026-02-09 19:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-15 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-22 09:06 |
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Articles in Press |
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2026-04-22 09:06 |
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Edit the Manuscript by Language Editor |
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2026-04-23 03:55 |
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Typeset the Manuscript |
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2026-05-13 01:07 |
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Publish the Manuscript Online |
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2026-05-25 07:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Opinion Review |
| Article Title |
GrpE-like 1-engineered synovial mesenchymal stromal cell exosomes: Mechanistic and translational priorities in osteoarthritis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen Shi, Hao-Yu Li, Bo-Kang Lv, Dong Li, Peng-Yu Lu, Xin-Yu Zhou, Meng-En Xue and Rui-Bo Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Scientific Research Projects of Colleges and Universities in Henan Province |
26A320038 |
| Henan Province Medical Science and Technology Research Plan Project (Joint Construction) |
LHGJ20250403, LHGJ20220566, LHGJ2024036 |
| Key Research and Development Program of Henan Province |
231111311000 |
| Medical Education Research Project in Henan Province |
WJLX2023079 |
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| Corresponding Author |
Rui-Bo Wang, Associate Chief Physician, MD, Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qian Street, Erqi District, Zhengzhou 450052, Henan Province, China. 18336397518@163.com |
| Key Words |
Cartilage regeneration; Engineered exosomes; GrpE-like 1; Mesenchymal stromal cells; Mitophagy; Mitochondrial homeostasis; Mitochondrial quality control; Osteoarthritis; Phosphatase and tensin homolog-induced kinase 1; Translational therapeutics |
| Core Tip |
Osteoarthritis still lacks reliable disease-modifying therapies. This review highlights an emerging mitochondria-centered strategy in which synovial mesenchymal stem cell-derived exosomes deliver GrpE-like 1 to engage the phosphatase and tensin homolog-induced kinase 1-dependent mitophagy pathway, improving mitochondrial homeostasis and cartilage outcomes across in vitro and in vivo models. We synthesize the mechanistic rationale and delineate the minimal translational checkpoints required for clinical readiness: Flux-based and specificity-anchored causal validation, chemistry, manufacturing, and controls - standardized product definition with mechanism-linked potency assays, and intra-articular pharmacokinetics/pharmacodynamics coupled to biomarker-driven patient stratification. |
| Publish Date |
2026-05-25 07:47 |
| Citation |
Shi Z, Li HY, Lv BK, Li D, Lu PY, Zhou XY, Xue ME, Wang RB. GrpE-like 1-engineered synovial mesenchymal stromal cell exosomes: Mechanistic and translational priorities in osteoarthritis. World J Stem Cells 2026; 18(5): 119231 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i5/119231.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i5.119231 |
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