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6/24/2026 9:14:07 AM | Browse: 0 | Download: 0
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 119272
Country China
Received
2026-01-23 05:59
Peer-Review Started
2026-01-23 06:01
First Decision by Editorial Office Director
2026-02-03 07:43
Return for Revision
2026-02-03 07:43
Revised
2026-02-11 23:33
Publication Fee Transferred
2026-02-13 05:01
Second Decision by Editor
2026-03-17 03:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-17 07:41
Articles in Press
2026-03-17 07:41
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-08 09:50
Publish the Manuscript Online
2026-06-24 09:14
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Cohort Study
Article Title Efficacy and safety of adjuvant targeted immunotherapy for hepatocellular carcinoma with high recurrence risks after hepatectomy
Manuscript Source Unsolicited Manuscript
All Author List Qi-Sen Li, An-Yin Hu, Shao-Jie Chen, Gong-Jin Yu, Yi Fan, Yi-Gang Chen, She Tian, Ci-Jun Peng and Min Han
ORCID
Author(s) ORCID Number
Qi-Sen Li http://orcid.org/0009-0006-0123-7511
Ci-Jun Peng http://orcid.org/0000-0001-8317-4820
Min Han http://orcid.org/0000-0001-7218-5276
Funding Agency and Grant Number
Funding Agency Grant Number
Guizhou Provincial Science and Technology Plan Project Qian-KH-[2024]-Youth-009
Corresponding Author Ci-Jun Peng, PhD, Professor, Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Guiyang 550001, Guizhou Province, China. doctorpengcijun@163.com
Key Words Hepatocellular carcinoma; Hepatectomy; Recurrence; Adjuvant therapy; Tyrosine kinase inhibitors; Immune-checkpoint inhibitors; Cohort study
Core Tip This retrospective cohort study demonstrates that adjuvant targeted and/or immunotherapy can significantly improve recurrence-free survival in hepatocellular carcinoma patients at high risk of recurrence after hepatectomy, compared to surgery alone. The therapy was identified as an independent protective factor against recurrence. While a clear overall survival benefit was not observed in this analysis, the treatment regimen showed a manageable safety profile, with most adverse events being reversible. These findings support the potential role of this adjuvant strategy in improving outcomes for this patient population.
Publish Date 2026-06-24 09:14
Citation

Li QS, Hu AY, Chen SJ, Yu GJ, Fan Y, Chen YG, Tian S, Peng CJ, Han M. Efficacy and safety of adjuvant targeted immunotherapy for hepatocellular carcinoma with high recurrence risks after hepatectomy. World J Gastrointest Surg 2026; 18(6): 119272

URL https://www.wjgnet.com/1948-9366/full/v18/i6/119272.htm
DOI https://doi.org/10.4240/wjgs.119272
Full Article (PDF) WJGS-18-119272-with-cover.pdf
STROBE Statement 119272-STROBE-statement.pdf
Manuscript File 119272_Auto_Edited_085244.docx
Answering Reviewers 119272-answering-reviewers.pdf
Audio Core Tip 119272-audio.mp3
Biostatistics Review Certificate 119272-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 119272-conflict-of-interest-statement.pdf
Copyright License Agreement 119272-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119272-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119272-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 119272-non-native-speakers.pdf
Peer-review Report 119272-peer-reviews.pdf
Scientific Misconduct Check 119272-scientific-misconduct-check.png
Scientific Editor Work List 119272-scientific-editor-work-list.pdf
CrossCheck Report 119272-crosscheck-report.pdf