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Articles Published Processes
5/20/2026 8:53:15 AM | Browse: 1 | Download: 0
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Received |
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2026-01-26 07:02 |
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Peer-Review Started |
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2026-01-26 07:03 |
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First Decision by Editorial Office Director |
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2026-01-29 08:40 |
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Return for Revision |
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2026-01-29 08:40 |
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Revised |
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2026-02-11 09:18 |
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Publication Fee Transferred |
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2026-02-13 00:32 |
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Second Decision by Editor |
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2026-03-26 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-26 07:15 |
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Articles in Press |
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2026-03-26 07:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-11 01:37 |
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Publish the Manuscript Online |
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2026-05-20 08:53 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Ma, Lei Wan, Yong-Yong Zhang, Ya-Ge Luo, Ning Yang, Fei-Fei Pu, Malik Ihsan Ullah Khan, Man Liu, Jin-Shan Liu and Ji-Tian Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Association of Chinese Medicine Young Talent Support Program |
2021-QNCRC2-A06 |
| the Traditional Chinese Medicine Research in Henan Province |
2023ZY2136 |
| Research Project of China Information Association of Traditional Chinese Medicine |
CACMS-KY-2023030-2023030 |
| Henan Province Collaborative Research Project on Traditional Chinese Medicine Science and Technology Special Program |
2025LHZX5043 |
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| Corresponding Author |
Ji-Tian Li, MD, PhD, Professor, Henan Provincial Health Commission Key Laboratory of Bone Metabolism and Analysis, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Henan University of Chinese Medicine, No. 100 Yongping Road, Zhengzhou 450046, Henan Province, China. jitianlee@hotmail.com |
| Key Words |
Osteosarcoma; Tumor associated antigen; Protein microarray; Detection; SRSF2; Biomarker |
| Core Tip |
Osteosarcoma (OS) is, a common malignant tumor, with no specific serological biomarker for early diagnosis. In this study, we focused on identifying novel autoantibodies against tumor associated antigens using the focused protein microarray based on cancer-driving genes for detecting OS. Three tumor associated antigens were identified through the focused protein microarray. Expression of these three autoantibodies was further detected by enzyme-linked immunosorbent assay, which was further validated by western blotting and immunohistochemistry. Serine/arginine-rich splicing factor 2 was identified as a potential serological biomarker for OS, and a possible supplementary screening approach. |
| Publish Date |
2026-05-20 08:53 |
| Citation |
Ma Y, Wan L, Zhang YY, Luo YG, Yang N, Pu FF, Khan MIU, Liu M, Liu JS, Li JT. Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray. World J Clin Oncol 2026; 17(5): 119275 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i5/119275.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i5.119275 |
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