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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 119293
Country China
Received
2026-01-27 07:03
Peer-Review Started
2026-01-27 07:04
First Decision by Editorial Office Director
2026-01-30 08:52
Return for Revision
2026-01-30 08:52
Revised
2026-02-12 02:36
Publication Fee Transferred
2026-02-14 02:15
Second Decision by Editor
2026-03-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-10 07:22
Articles in Press
2026-03-10 07:22
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-13 02:13
Publish the Manuscript Online
2026-04-24 10:11
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology & Pharmacy
Manuscript Type Prospective Study
Article Title Impact of oxiracetam on postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery
Manuscript Source Unsolicited Manuscript
All Author List Bao-Sheng Lv, Wei Wang, Mu Jin, Yan Ma, Jia-Lu Wang and Hui Gao
ORCID
Author(s) ORCID Number
Wei Wang http://orcid.org/0009-0005-0945-5954
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Hebei Province H2021103001
Corresponding Author Wei Wang, MD, Department of Neurology, Hebei Yanda Hospital, Yanjiao Development Zone, Langfang 065201, Hebei Province, China. ww19333643617@163.com
Key Words Postoperative delirium; Aged; Oxiracetam; Laparoscopic surgery; Inflammation; Randomized controlled trial
Core Tip Perioperative intravenous oxiracetam safely and effectively reduces the risk of postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery, and maintains postoperative cognitive functionality. Its protective effect likely involves multi-target mechanisms, including stabilization complex modulation of the systemic immune response, rather than dependence on simple suppression of a single inflammatory pathway. This study provides a foundation for the clinical application of oxiracetam as a perioperative brain protection strategy for elderly surgical patients.
Publish Date 2026-04-24 10:11
Citation

Lv BS, Wang W, Jin M, Ma Y, Wang JL, Gao H. Impact of oxiracetam on postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal surgery. World J Gastrointest Surg 2026; 18(4): 119293

URL https://www.wjgnet.com/1948-9366/full/v18/i4/119293.htm
DOI https://dx.doi.org/10.4240/wjgs.v18.i4.119293
Full Article (PDF) WJGS-18-119293-with-cover.pdf
CONSORT 2010 Statement 119293-CONSORT-2010-statement.pdf
Manuscript File 119293_Auto_Edited_033642.docx
Answering Reviewers 119293-answering-reviewers.pdf
Audio Core Tip 119293-audio.m4a
Biostatistics Review Certificate 119293-biostatistics-statement.pdf
Clinical Trial Registration Statement 119293-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 119293-conflict-of-interest-statement.pdf
Copyright License Agreement 119293-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119293-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119293-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 119293-non-native-speakers.pdf
Peer-review Report 119293-peer-reviews.pdf
Scientific Misconduct Check 119293-scientific-misconduct-check.png
Scientific Editor Work List 119293-scientific-editor-work-list.pdf
CrossCheck Report 119293-crosscheck-report.pdf