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Articles Published Processes
6/17/2026 6:55:11 AM | Browse: 1 | Download: 2
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Received |
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2026-01-26 01:46 |
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Peer-Review Started |
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2026-01-26 01:46 |
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First Decision by Editorial Office Director |
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2026-01-30 09:05 |
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Return for Revision |
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2026-01-30 09:05 |
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Revised |
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2026-02-01 17:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-21 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-21 08:47 |
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Articles in Press |
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2026-04-21 08:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-04 09:25 |
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Publish the Manuscript Online |
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2026-06-17 06:55 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Extended antibiotic prophylaxis in primary total knee arthroplasty: A narrative review of current evidence and controversies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tarun Jayakumar, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Periprosthetic joint infection; Antibiotics; Extended spectrum; Antimicrobial resistance; Antibiotic stewardship |
| Core Tip |
Extended oral antibiotic prophylaxis after primary total knee arthroplasty has not demonstrated consistent benefit in reducing periprosthetic joint infection compared with standard ≤ 24-hour regimens. While early retrospective data suggested possible value in high-risk patients, larger studies and meta-analyses show no advantage and highlight antimicrobial resistance concerns. Current international guidelines recommend limiting prophylaxis to 24 hours, with future randomized trials needed to clarify extended oral antibiotic’s role in selected populations. |
| Publish Date |
2026-06-17 06:55 |
| Citation |
Jayakumar T, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. Extended antibiotic prophylaxis in primary total knee arthroplasty: A narrative review of current evidence and controversies. World J Orthop 2026; 17(6): 119301
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| URL |
https://www.wjgnet.com/2218-5836/full/v17/i6/119301.htm |
| DOI |
https://doi.org/10.5312/wjo.v17.i6.119301 |
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