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Articles Published Processes
9/28/2026 8:29:03 AM | Browse: 0 | Download: 0
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Received |
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2026-01-26 01:20 |
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Peer-Review Started |
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2026-01-26 01:20 |
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First Decision by Editorial Office Director |
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2026-02-27 09:06 |
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Return for Revision |
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2026-02-27 09:06 |
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Revised |
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2026-03-09 14:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-06 03:20 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-06 07:33 |
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Articles in Press |
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2026-05-06 07:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-26 03:18 |
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Publish the Manuscript Online |
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2026-09-28 08:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Opinion Review |
| Article Title |
RHEB-CSF1R signaling, autophagy, and metastatic plasticity in pancreatic cancer: Current advances, controversies, and translational opportunities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jun-Xia Hu, Ye Zhang, Yue-Mei Chen and Lei Cao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lei Cao, Chief Physician, PhD, Professor, Department of Oncology, Jiangsu Province (Suqian) Hospital, No. 120 Suzhi Road, Sucheng District, Suqian 223800, Jiangsu Province, China. brawnym80@163.com |
| Key Words |
Pancreatic cancer; Ras homolog enriched in brain; Colony stimulating factor 1 receptor; Autophagy; Phosphatidylinositol 3-kinase/protein kinase B/mammalian pathway; Epithelial-mesenchymal transition; Metastasis; Tumor microenvironment |
| Core Tip |
A recent study comprehensively summarized that a tumor-cell ras homolog enriched in brain-colony stimulating factor 1 receptor complex promotes pancreatic cancer metastasis by increasing phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin phosphorylation, suppressing autophagy, and inducing epithelial-mesenchymal transition. Building on this work, the present article discusses how ras homolog enriched in brain-centered signaling may connect tumor-cell metabolic adaptation, macrophage-associated biology, autophagy regulation, and metastatic plasticity in pancreatic ductal adenocarcinoma. We emphasize current advances, major controversies, and translational opportunities, with particular focus on tumor-cell colony stimulating factor 1 receptor, autophagic flux, and biomarker-guided therapeutic development. |
| Publish Date |
2026-09-28 08:29 |
| Citation |
Hu JX, Zhang Y, Chen YM, Cao L. RHEB-CSF1R signaling, autophagy, and metastatic plasticity in pancreatic cancer: Current advances, controversies, and translational opportunities. World J Gastroenterol 2026; 32(43): 119315
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i43/119315.htm |
| DOI |
https://doi.org/10.3748/wjg.v32.i43.119315 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
