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Articles Published Processes
5/19/2026 7:13:10 AM | Browse: 3 | Download: 0
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Received |
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2026-02-02 01:26 |
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Peer-Review Started |
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2026-02-02 01:28 |
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First Decision by Editorial Office Director |
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2026-02-14 07:40 |
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Return for Revision |
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2026-02-14 07:40 |
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Revised |
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2026-03-05 04:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-10 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-10 04:03 |
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Articles in Press |
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2026-04-10 04:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-13 01:02 |
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Publish the Manuscript Online |
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2026-05-19 07:13 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Mechanistic convergence of exercise and mesenchymal stem cell-derived exosome signaling in isoproterenol-induced myocardial injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jacob Strouse, Stevenson Cottiere and Brandon Lucke-Wold |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jacob Strouse, Doctorate Student, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th St AHC2, Miami, FL 33138, United States. jstro026@fiu.edu |
| Key Words |
Myocardial ischemia; Isoproterenol; Mesenchymal stem cell; Exosomes; Nanoparticles; ERK; Exercise; AKT/mTOR |
| Core Tip |
Exercise primes cardiomyocyte stress tolerance through ERK and PI3K/Akt/mTOR pathway activation, regulated autophagy, and mitochondrial preservation, while mesenchymal stem cell-derived exosomes reinforce these same survival networks via paracrine delivery of bioactive cargo. Integrating exercise conditioning with targeted, cell-free exosome-based strategies may overcome current therapeutic plateaus by enhancing biological engagement, improving myocardial resilience, and biasing post-ischemic remodeling toward adaptive recovery. |
| Publish Date |
2026-05-19 07:13 |
| Citation |
Strouse J, Cottiere S, Lucke-Wold B. Mechanistic convergence of exercise and mesenchymal stem cell-derived exosome signaling in isoproterenol-induced myocardial injury. World J Cardiol 2026; 18(5): 119321 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i5/119321.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i5.119321 |
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