BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/20/2026 8:22:31 AM | Browse: 1 | Download: 0
 |
Received |
|
2026-01-26 01:18 |
|
Peer-Review Started |
|
2026-01-26 01:20 |
|
First Decision by Editorial Office Director |
|
2026-02-13 08:13 |
|
Return for Revision |
|
2026-02-13 08:13 |
|
Revised |
|
2026-03-01 07:39 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-03-13 02:43 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-03-13 06:15 |
|
Articles in Press |
|
2026-03-13 06:15 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-05-13 01:04 |
|
Publish the Manuscript Online |
|
2026-05-20 08:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Opinion Review |
| Article Title |
Adjacent nontumor mucosa: The overlooked frontier in colorectal cancer prognostication
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Jing Zhao and Xin-Yun Qiu |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Xin-Yun Qiu, Adjunct Associate Professor, MD, PhD, Visiting Professor, Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States. qiuxinyun2819@126.com |
| Key Words |
Colorectal cancer; Adjacent nontumor mucosa; Macrophage polarization; Liver metastases; Prognostic biomarkers |
| Core Tip |
Most immune profiling in colorectal cancer focuses on the tumor core, overlooking adjacent nontumor mucosa (NM). Ye et al show that NM macrophage subsets provide stage-specific prognostic signals after liver metastasectomy: Higher CD80-positive (M1-like) macrophages predict longer survival in stage I-III, while higher CD163-positive (M2-like) macrophages predict longer survival in stage IV. Tumor center metrics were not predictive. Incorporating NM immune profiling (CD80, CD163), alongside T-cell measures, could refine risk stratification and guide stage-tailored immune modulation. |
| Publish Date |
2026-05-20 08:22 |
| Citation |
Zhao XJ, Qiu XY. Adjacent nontumor mucosa: The overlooked frontier in colorectal cancer prognostication. World J Gastroenterol 2026; 32(20): 119322 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i20/119322.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i20.119322 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
