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Articles Published Processes
10/26/2026 6:39:39 AM | Browse: 0 | Download: 0
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Received |
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2026-04-22 10:16 |
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Peer-Review Started |
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2026-04-22 10:16 |
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First Decision by Editorial Office Director |
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2026-05-15 10:08 |
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Return for Revision |
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2026-05-15 10:08 |
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Revised |
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2026-06-16 15:27 |
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Publication Fee Transferred |
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2026-06-29 01:30 |
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Second Decision by Editor |
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2026-07-27 02:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-20 09:34 |
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Articles in Press |
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2026-10-20 09:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-21 03:17 |
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Publish the Manuscript Online |
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2026-10-26 06:39 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Basic Study |
| Article Title |
Therapeutic potential of umbilical cord-derived mesenchymal stem cells in ameliorating ovarian aging: Insights from single-cell analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Ning Zhang, Shuang Tian, Xin-Meng Guo, Qi Zhang, Jin Shang and Yuan-Qing Yao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yuan-Qing Yao, Senior Department of Obstetrics and Gynecology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100010, China. yao_yuanqing@126.com |
| Key Words |
Ovarian aging; Mesenchymal stem cells; Aged control; Single-cell RNA; Umbilical cord-derived mesenchymal stem cell |
| Core Tip |
This study demonstrates that umbilical cord-derived mesenchymal stem cells (UCMSCs) effectively alleviate ovarian aging in aged mice and enhance oocyte quality. Single-cell transcriptomic analysis revealed that UCMSC treatment led to increased mitochondrial oxidative phosphorylation, elevated Klotho expression, and suppression of aging-related pathways. Additionally, UCMSCs improved intercellular communication within the ovary and influenced the developmental trajectory of granulosa cells. These findings elucidate the mechanisms underlying UCMSC-mediated ovarian rejuvenation and highlight their therapeutic potential for addressing age-related ovarian decline. |
| Publish Date |
2026-10-26 06:39 |
| Citation |
Zhang JN, Tian S, Guo XM, Zhang Q, Shang J, Yao YQ. Therapeutic potential of umbilical cord-derived mesenchymal stem cells in ameliorating ovarian aging: Insights from single-cell analysis. World J Stem Cells 2026; 18(10): 119325
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i10/119325.htm |
| DOI |
https://doi.org/10.4252/wjsc.119325 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
