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11/3/2026 4:47:24 AM | Browse: 2 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 119352
Country Romania
Received
2026-01-26 03:02
Peer-Review Started
2026-01-26 03:13
First Decision by Editorial Office Director
2026-02-09 09:50
Return for Revision
2026-02-09 09:50
Revised
2026-02-20 21:51
Publication Fee Transferred
Second Decision by Editor
2026-05-09 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-09 11:25
Articles in Press
2026-05-09 11:25
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-26 03:18
Publish the Manuscript Online
2026-11-03 04:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Application of spatial omics, multi-omics, and artificial intelligence in inflammatory bowel disease: Current applications and emerging opportunities
Manuscript Source Unsolicited Manuscript
All Author List Charles Adolfu Shirima, Gibson Albert Sabuholo, Lucia Bubulac, Priya Patel and Gratiela Gradisteanu Pircalabioru
ORCID
Author(s) ORCID Number
Charles Adolfu Shirima http://orcid.org/0000-0002-6060-5701
Gibson Albert Sabuholo http://orcid.org/0009-0002-9210-612X
Lucia Bubulac http://orcid.org/0000-0002-1541-9870
Priya Patel http://orcid.org/0009-0002-6180-032X
Gratiela Gradisteanu Pircalabioru http://orcid.org/0000-0002-6384-1822
Funding Agency and Grant Number
Corresponding Author Gratiela Gradisteanu Pircalabioru, Academic Fellow, Associate Professor, Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, sos Panduri 90, Bucharest 030014, Romania. gratiela.gradisteanu@icub.unibuc.ro
Key Words Inflammatory bowel disease; Multi-omics; Crohn’s disease; Artificial intelligence; Spatial-omics; Ulcerative colitis; Microbiota
Core Tip Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, arises from complex, spatially organized interactions between host genetics, immune responses, epithelial integrity, and the intestinal microbiota. Emerging multi-omics and spatial-omics technologies now enable high-resolution, tissue-context-preserved profiling of these processes, revealing disease-defining cellular niches and host-microbiome interactions. Artificial intelligence (AI) provides a critical framework for integrating high-dimensional datasets, uncovering non-linear relationships, and translating molecular complexity into clinically actionable insights. The convergence of multi-omics, spatial-omics, and AI holds strong promise for precision medicine in IBD, enabling improved disease stratification, identification of spatial biomarkers for progression and cancer risk, and the development of next-generation, non-animal disease models.
Publish Date 2026-11-03 04:47
Citation

Shirima CA, Sabuholo GA, Bubulac L, Patel P, Gradisteanu Pircalabioru G. Application of spatial omics, multi-omics, and artificial intelligence in inflammatory bowel disease: Current applications and emerging opportunities. World J Gastroenterol 2026; 32(48): 119352

URL https://www.wjgnet.com/1007-9327/full/v32/i48/119352.htm
DOI https://doi.org/10.3748/wjg.119352
Full Article (PDF) WJG-32-119352-with-cover.pdf
Manuscript File 119352_Auto_Edited_012206.docx
Answering Reviewers 119352-answering-reviewers.pdf
Audio Core Tip 119352-audio.mp3
Conflict-of-Interest Disclosure Form 119352-conflict-of-interest-statement.pdf
Copyright License Agreement 119352-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 119352-non-native-speakers.pdf
Peer-review Report 119352-peer-reviews.pdf
Scientific Misconduct Check 119352-scientific-misconduct-check.png
CrossCheck Report 119352-crosscheck-report.pdf