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Articles Published Processes
7/17/2026 8:23:29 AM | Browse: 1 | Download: 0
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Received |
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2026-01-27 06:02 |
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Peer-Review Started |
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2026-01-27 06:04 |
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First Decision by Editorial Office Director |
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2026-02-04 10:11 |
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Return for Revision |
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2026-02-04 10:11 |
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Revised |
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2026-02-13 22:56 |
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Publication Fee Transferred |
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2026-02-19 13:43 |
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Second Decision by Editor |
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2026-03-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-26 05:54 |
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Articles in Press |
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2026-03-26 05:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-26 06:29 |
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Publish the Manuscript Online |
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2026-07-17 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Woo Kim, Hak Jin Kim, Seon Hee Choi and Mi Sook Yun |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hak Jin Kim, PhD, Professor, Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University College of Medicine, 179 Gudeok-ro, Seo-gu, Busan 49241, South Korea. hakjink@pusan.ac.kr |
| Key Words |
Transcatheter arterial chemoembolization; Hepatocellular carcinoma; VX2 tumor; Liver; Doxorubicin; Triolein emulsion |
| Core Tip |
The infusion of triolein emulsion into the hepatic arteries increased the liver vascular permeability in the sinusoidal capillaries by transiently disrupting endothelial barriers, leading to a minimal transient decrease in liver function without specific histopathological changes in the rabbit livers. Consequently, any triolein-induced endothelial loosening can substantially enhance drug extravasation into liver tissue. This study aimed to evaluate the antitumor effects of doxorubicin by comparing the changes in tumor volume and the growth ratios between the triolein emulsion with doxorubicin and normal saline with doxorubicin groups via a hepatic arterial infusion in a rabbit liver VX2 tumor model. |
| Publish Date |
2026-07-17 08:23 |
| Citation |
Kim YW, Kim HJ, Choi SH, Yun MS. Enhancing delivery of doxorubicin using triolein emulsion in rabbit VX2 liver tumor model. World J Gastroenterol 2026; 32(29): 119374
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i29/119374.htm |
| DOI |
https://doi.org/10.3748/wjg.119374 |
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