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Articles Published Processes
4/9/2026 3:52:16 AM | Browse: 2 | Download: 13
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Received |
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2026-01-27 05:47 |
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Peer-Review Started |
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2026-01-27 05:50 |
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First Decision by Editorial Office Director |
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2026-02-28 06:48 |
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Return for Revision |
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2026-02-28 06:48 |
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Revised |
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2026-02-28 09:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-11 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-11 08:23 |
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Articles in Press |
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2026-03-11 08:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-30 02:25 |
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Publish the Manuscript Online |
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2026-04-09 03:52 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Ophthalmology |
| Manuscript Type |
Minireviews |
| Article Title |
Gene therapy for diabetic retinopathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Matteo Capobianco, Simonetta Gaia Nicolosi, Francesco Cappellani, Marieme Khouyyi, Fabiana D’Esposito, Caterina Gagliano and Marco Zeppieri |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it |
| Key Words |
Diabetic retinopathy; Diabetic macular edema; Gene therapy; Retinal biofactory; Adeno-associated virus; Suprachoroidal delivery; Inflammation; Neurovascular unit; Genome editing |
| Core Tip |
Gene therapy for diabetic retinopathy is developing as a method to diminish the want for regular intravitreal injections by offering prolonged intraocular modulation of disease pathways. Extensive experience with age-related macular degeneration provides compelling clinical evidence that sustained suppression of pathological vascular signaling is feasible, while preliminary studies on diabetic retinopathy are evaluating the potential for similar durability within the inflammatory diabetic retinal milieu. Significant obstacles to translation encompass delivery- and dose-associated intraocular inflammation, ambiguity concerning long-term efficacy and the practicality of repeated dosage, as well as the necessity for stringent patient selection and monitoring. |
| Publish Date |
2026-04-09 03:52 |
| Citation |
Capobianco M, Nicolosi SG, Cappellani F, Khouyyi M, D’Esposito F, Gagliano C, Zeppieri M. Gene therapy for diabetic retinopathy. World J Clin Cases 2026; 14(11): 119413 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i11/119413.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i11.119413 |
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