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Articles Published Processes
4/24/2026 5:43:48 AM | Browse: 2 | Download: 12
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Received |
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2026-02-02 02:47 |
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Peer-Review Started |
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2026-02-02 02:48 |
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First Decision by Editorial Office Director |
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2026-02-10 10:54 |
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Return for Revision |
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2026-02-10 10:54 |
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Revised |
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2026-02-23 15:04 |
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Publication Fee Transferred |
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2026-02-25 11:54 |
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Second Decision by Editor |
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2026-03-17 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-17 09:54 |
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Articles in Press |
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2026-03-17 09:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-10 06:34 |
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Publish the Manuscript Online |
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2026-04-24 05:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Insights into the pathogenic roles and targeted therapy of neutrophil extracellular traps in inflammatory bowel disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Qi, Liang Ma, Yin Zhang, Yi Liu, Min Su, Ting-Ting Cai, Mei Wang and Ke-Wen Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Changzhou Applied Basic Research Program |
No. CJ20220091 |
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| Corresponding Author |
Ke-Wen Sun, Chief Physician, Department of Gastroenterology, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Tianning District, Changzhou 213004, Jiangsu Province, China. sunkewen0727@suda.edu.cn |
| Key Words |
Inflammatory bowel disease; Neutrophil extracellular traps; Mucosal immunity; Mechanism; Clinical translation |
| Core Tip |
Neutrophil extracellular traps (NETs), while essential for pathogen clearance, act as a double-edged sword in inflammatory bowel diseases (IBDs). Excessive accumulation of NETs has been confirmed in IBD patients and colitis mouse model. NET components can exacerbate chronic intestinal inflammation, destroy intestinal mucosal barrier and aggravate tissue damage, promote thrombosis and colitis-associated cancer. Consequently, therapeutic strategies targeting NET formation or promoting NET degradation are emerging as promising avenues to restore intestinal mucosal homeostasis in IBD. |
| Publish Date |
2026-04-24 05:43 |
| Citation |
Qi Y, Ma L, Zhang Y, Liu Y, Su M, Cai TT, Wang M, Sun KW. Insights into the pathogenic roles and targeted therapy of neutrophil extracellular traps in inflammatory bowel disease. World J Gastroenterol 2026; 32(17): 119419 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i17/119419.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i17.119419 |
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