| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Wang Fan, Jia-Zhe Hou, Yi-Zhe Wang, Ming-Lin Gao, Ying Shen, Dai Jian, Qin Zhou, Jing Yang, Hui Zhao and Li-Juan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81872720 |
| the Shanghai Municipal Health Commission |
2023ZZ02027 |
| the National Clinical Key Specialty Construction Project of China |
Z155080000004 |
|
| Corresponding Author |
Li-Juan Zhang, PhD, Health Management Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, No. 50 Chifeng Road, Yangpu District, Shanghai 201613, China. zhangxiaoyi@tongji.edu.cn |
| Key Words |
Adolescent depression; Lymphocyte count; Lymphocyte-to-monocyte ratio; Peripheral immunity; Severity; Multicenter study |
| Core Tip |
This two-stage multicenter study reveals a divergent immunopurified in first-episode, drug-naive adolescents with major depressive disorder. While patients exhibited significantly lower lymphocyte counts and lymphocyte-to-monocyte ratios than healthy controls, higher levels of these markers paradoxically correlated with greater disease severity, particularly in females. A composite model integrating these indices demonstrated robust diagnostic discrimination (area under the curve = 0.82). These findings support a stage-dependent immunopsychiatric paradigm, suggesting that routine peripheral immune metrics offer a practical, objective tool for identifying major depressive disorder and stratifying severity in youth. |
| Publish Date |
2026-06-30 11:45 |
| Citation |
Fan XW, Hou JZ, Wang YZ, Gao ML, Shen Y, Jian D, Zhou Q, Yang J, Zhao H, Zhang LJ. Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study. World J Psychiatry 2026; 16(7): 119439
|
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i7/119439.htm |
| DOI |
https://doi.org/10.5498/wjp.119439 |
